| Dietary sulfur amino acid effects on fasting plasma cysteine/cystine redox potential in humans. | |
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MedLine Citation:
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PMID: 20471805 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Oxidation of plasma cysteine/cystine (Cys/CySS) redox potential (E(h)CySS) has been associated with risk factors for cardiovascular disease in humans. Cys and CySS are derived from dietary sulfur amino acids (SAA), but the specific effects of SAA depletion and repletion on Cys/CySS redox indices are unknown. The present study examined the effect of dietary SAA intake level on free Cys, free CySS, and E(h)CySS in human plasma under fasting conditions. METHODS: Healthy individuals aged 18-36 y (n = 13) were equilibrated to foods providing the RDA for SAA and then fed chemically defined diets without SAA (0 mg · kg(-1) · d(-1); n = 13) followed by SAA at levels approximating the mean (56 mg · kg(-1) · d(-1); n = 8) or 99th percentile (117 mg · kg(-1) · d(-1); n = 5) intake levels of Americans. Fasting plasma samples were collected daily during 4-d study periods and analyzed for free Cys, free CySS, and the E(h)CySS. RESULTS: The SAA-free diet significantly (P < 0.05) decreased plasma-free Cys concentrations and oxidized E(h)CySS values after 4 d of SAA depletion. With SAA repletion at 56 mg · kg(-1) · d(-1), plasma-free Cys increased significantly and values for E(h)CySS became more reduced. Administration of a diet providing a higher dose of SAA (117 mg · kg(-1) · d(-1)) resulted in a significantly higher level of free Cys and a more reduced E(h)CySS. CONCLUSIONS: These results show that free Cys and Cys/CySS redox potential (E(h)CySS) in fasting plasma are affected by dietary SAA intake level in humans. Significant changes occur slowly over 4 d with insufficient SAA intake, but rapidly (after 1 d) with repletion. |
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Authors:
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Dean P Jones; Youngja Park; Nana Gletsu-Miller; Yongliang Liang; Tianwei Yu; Carolyn Jonas Accardi; Thomas R Ziegler |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-05-14 |
Journal Detail:
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Title: Nutrition (Burbank, Los Angeles County, Calif.) Volume: 27 ISSN: 1873-1244 ISO Abbreviation: Nutrition Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-10 Completed Date: 2011-04-18 Revised Date: 2012-02-02 |
Medline Journal Info:
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Nlm Unique ID: 8802712 Medline TA: Nutrition Country: United States |
Other Details:
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Languages: eng Pagination: 199-205 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Division of Pulmonary, Allergy and Critical Care Medicine, Emory University, Atlanta, Georgia, USA. dpjones@emory.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Amino Acids, Sulfur / administration & dosage*, adverse effects Cardiovascular Diseases / epidemiology Cysteine / blood* Cystine / blood* Diet Dietary Proteins / administration & dosage*, adverse effects Fasting Female Humans Male Oxidation-Reduction Oxidative Stress Plasma / metabolism* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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DK55850/DK/NIDDK NIH HHS; ES011195/ES/NIEHS NIH HHS; ES012929/ES/NIEHS NIH HHS; K24 RR023356/RR/NCRR NIH HHS; K24 RR023356-05/RR/NCRR NIH HHS; M01 RR000039-460679/RR/NCRR NIH HHS; M01 RR000039-475542/RR/NCRR NIH HHS; M01 RR00039/RR/NCRR NIH HHS; R01 DK055850-04/DK/NIDDK NIH HHS; R01 ES009047-11/ES/NIEHS NIH HHS; R01 ES011195-03/ES/NIEHS NIH HHS; R01 ES011195-10/ES/NIEHS NIH HHS; R03 DK066008-02/DK/NIDDK NIH HHS; R03 ES012929-01/ES/NIEHS NIH HHS; UL1 RR025008/RR/NCRR NIH HHS; UL1 RR025008-01/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids, Sulfur; 0/Dietary Proteins; 52-90-4/Cysteine; 56-89-3/Cystine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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