Document Detail


Dietary sucrose intake is related to serum leptin concentration in overweight pregnant women.
MedLine Citation:
PMID:  19727896     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Overweight, characterized by low-degree systemic inflammation, predisposes women to impaired glucose metabolism during pregnancy. Adipokine leptin participates in the regulation of energy balance and immune action. AIMS OF THE STUDY: Objective of the study was to evaluate if aberrations in glucose metabolism during pregnancy are related to leptin concentration and whether serum leptin concentration is affected by diet composition. SUBJECTS AND METHODS: Normal-weight (n = 61) and overweight or obese (BMI > 25, n = 42) pregnant women visited study clinic at third trimester of pregnancy and one month postpartum. Serum fasting leptin and insulin as well as plasma glucose concentrations were measured, insulin resistance (HOMA) and sensitivity (QUICKI) calculated, and dietary intake from food records determined. RESULTS: In overweight women leptin concentration was significantly higher both in pregnancy, 45.27 (95% CI 39.40-51.14) ng/ml, and postpartum, 31.84 (27.38-36.30) ng/ml, than in normal-weight women, 31.09 (95% CI 27.80-34.37) ng/ml and 16.23 (13.93-18.53) ng/ml, respectively. Equally, blood glucose concentration during pregnancy was higher, 4.82 (4.67-4.97)mmol/l, and insulin concentration, 15.34 (12.00-18.68) mU/l, more pronounced in overweight compared to normal-weight women, 4.51 (4.42-4.61) mmol/l and 8.28 (7.21-9.36) mU/l, respectively. Significantly higher HOMA and lower QUICKI were also detected in overweight compared to normal-weight women. At third trimester of pregnancy, leptin concentration correlated positively with insulin concentration in normal-weight (r = 0.561, P = 0.002) and overweight women (r = 0.736, P < 0.001), as well as with HOMA (r = 0.568, P = 0.002 and r = 0.731, P < 0.001, respectively) whereas negative association was found with QUICKI in normal-weight (r = -0.484, P = 0.011) and overweight women (r = -0.711, P < 0.001). Importantly, serum leptin concentration was affected by dietary sucrose intake both as quantitatively (r = 0.424, P = 0.009) and relative to energy intake (r = 0.408, P = 0.012) in overweight but not in normal-weight pregnant women. CONCLUSIONS: Overweight-related elevation in serum leptin is associated with impaired regulation of glucose metabolism during pregnancy. The novel finding that dietary sucrose intake is related to serum leptin concentration is in line with the current dietary recommendations to overweight pregnant women with impaired glucose metabolism advising the lower intake of sucrose during pregnancy.
Authors:
Sanna V?h?miko; Erika Isolauri; Ullamari Pesonen; Pertti Koskinen; Ulla Ekblad; Kirsi Laitinen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-29
Journal Detail:
Title:  European journal of nutrition     Volume:  49     ISSN:  1436-6215     ISO Abbreviation:  Eur J Nutr     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-09     Completed Date:  2010-04-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888704     Medline TA:  Eur J Nutr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  83-90     Citation Subset:  IM    
Affiliation:
Functional Foods Forum, University of Turku, Turku, Finland. sanvah@utu.fi
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MeSH Terms
Descriptor/Qualifier:
Blood Glucose / analysis
Body Mass Index
Diet
Diet Records
Dietary Sucrose / administration & dosage*
Energy Intake
Female
Humans
Insulin / blood
Insulin Resistance
Leptin / blood*
Overweight / blood,  complications*
Postpartum Period / blood
Pregnancy
Pregnancy Complications / blood*
Pregnancy Trimester, Third / blood
Statistics as Topic
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Sucrose; 0/Leptin; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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