| Dietary strategies for patients with type 2 diabetes in the era of multi-approaches; review and results from the Dietary Intervention Randomized Controlled Trial (DIRECT). | |
| | |
MedLine Citation:
|
PMID: 20115931 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Dietary intervention is recognized as a key component in prevention and management of type 2 diabetes (T2DM) and the debate persists: which dietary strategy is most effective. In the Dietary Intervention Randomized Controlled Trial (DIRECT) 322 moderately obese participants were randomized for 2 years to one of three diet groups: low-fat, Mediterranean and low-carbohydrate. Differential effects were observed in the sub-group of patients with T2DM at 24 months: participants randomized to the Mediterranean diet, which had the highest intake of dietary fibers and unsaturated to saturated fat ratio, achieved greater significant improvements in fasting plasma glucose and insulin levels. Patients who were randomized to the low-carbohydrate diet, which had the minimal intake of carbohydrates, achieved a significant reduction of hemoglobin A1C. Although improvements were observed in all groups, the low-fat diet was likely to be less beneficial in terms of glycemic control and lipid metabolism. Interpretation of results from different studies on dietary strategies may be complex since there is often no consistency in diet compositions, calorie restriction, intensity of intervention, dietary assessment or extent of adherence in the trial. Nevertheless, it seems that low fat restricted calorie diets are effective for weight loss and are associated with some metabolic benefits; however, some recent trials have shown that low carbohydrate diets are as efficient in inducing weight loss and in some metabolic measures such as serum triglycerides and HDL-cholesterol may be even superior to low fat diets. When addressing the issue of diet quality rather than quantity applying the glycemic index may have some added benefits. Furthermore special features of the Mediterranean diet have apparent additional favorable effects for patients with T2DM. |
| | |
Authors:
|
Sivan Ben-Avraham; Ilana Harman-Boehm; Dan Schwarzfuchs; Iris Shai |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Diabetes research and clinical practice Volume: 86 Suppl 1 ISSN: 1872-8227 ISO Abbreviation: Diabetes Res. Clin. Pract. Publication Date: 2009 Dec |
Date Detail:
|
Created Date: 2010-02-01 Completed Date: 2010-04-23 Revised Date: 2010-06-07 |
Medline Journal Info:
|
Nlm Unique ID: 8508335 Medline TA: Diabetes Res Clin Pract Country: Ireland |
Other Details:
|
Languages: eng Pagination: S41-8 Citation Subset: IM |
Copyright Information:
|
Copyright 2009 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
The S. Daniel Abraham Center for Health and Nutrition, Department of Epidemilogy, Ben-Gurion University of the Negev, Beer-Sheva, Israel. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Body Mass Index Diabetes Mellitus, Type 2 / complications, diet therapy* Diabetic Diet* Diet, Fat-Restricted Diet, Mediterranean Diet, Reducing Humans Middle Aged Obesity / complications Randomized Controlled Trials as Topic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Diabetes care targets in older persons.
Next Document: Self-monitoring of blood glucose in treatment of type 2 diabetes.