| Dietary soy and tea mitigate chronic inflammation and prostate cancer via NFκB pathway in the Noble rat model. | |
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MedLine Citation:
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PMID: 20801632 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic inflammation and nuclear factor-kappa B (NFκB) have been implicated in prostate cancer development; thus, dietary factors that inhibit NFκB may serve as effective chemo-preventative agents. Prostate cancer risk is significantly lower in Asian countries compared to the United States, which has prompted interest in the potential chemopreventative action of Asian dietary components such as soy and green tea. This study examined the effects of dietary soy and tea on NFκB activation and inflammation in vivo using a hormone-induced rat model for prostate cancer. Male Noble rats implanted with estradiol and testosterone were divided into 4 dietary groups: control, soy, tea, or soy+tea. NFκB activation and inflammatory cytokines were measured post implantation. The combination of soy and tea suppressed NFκB p50 binding activity and protein levels via induction of IκBα. Soy and tea also decreased prostate inflammatory infiltration, increased Bax/BcL2 ratio and decreased protein expression of tumor necrosis factor-alpha, interleukin (IL)-6 and IL-1β compared to control. Soy and tea attenuated prostate malignancy by decreasing prostate hyperplasia. These effects were not apparent in groups treated with soy or tea alone. The ongoing in vivo studies thus far suggest that combination of foods, such as soy and tea, may inhibit hormone-induced proinflammatory NFκB signals that contribute to prostate cancer development. |
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Authors:
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Anna Hsu; Richard S Bruno; Christiane V Löhr; Alan W Taylor; Rodrick H Dashwood; Tammy M Bray; Emily Ho |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of nutritional biochemistry Volume: 22 ISSN: 1873-4847 ISO Abbreviation: J. Nutr. Biochem. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-18 Completed Date: 2011-08-15 Revised Date: 2012-05-02 |
Medline Journal Info:
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Nlm Unique ID: 9010081 Medline TA: J Nutr Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 502-10 Citation Subset: IM |
Copyright Information:
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Published by Elsevier Inc. |
Affiliation:
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Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Inflammatory Agents / pharmacology* Antineoplastic Agents / pharmacology* Catechin / analysis, pharmacology Chronic Disease Diet Disease Models, Animal Estradiol / blood I-kappa B Proteins / metabolism Inflammation / drug therapy Interleukin-1beta / metabolism Interleukin-6 / metabolism Isoflavones / blood Male NF-kappa B / metabolism* Prostatic Neoplasms / drug therapy*, prevention & control Rats Signal Transduction Soy Foods / analysis Soybeans / chemistry* Tea / chemistry* Testosterone / blood Tumor Necrosis Factor-alpha / metabolism bcl-2-Associated X Protein / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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CA107693/CA/NCI NIH HHS; CA909890/CA/NCI NIH HHS; P30 ES00210/ES/NIEHS NIH HHS; R01 CA107693-05/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Antineoplastic Agents; 0/Bax protein, rat; 0/I-kappa B Proteins; 0/Interleukin-1beta; 0/Interleukin-6; 0/Isoflavones; 0/NF-kappa B; 0/Tea; 0/Tumor Necrosis Factor-alpha; 0/bcl-2-Associated X Protein; 139874-52-5/NF-kappaB inhibitor alpha; 154-23-4/Catechin; 4737-27-3/isoflavanone; 50-28-2/Estradiol; 58-22-0/Testosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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