| Dietary soy protein benefit in experimental kidney disease is preserved after isoflavone depletion of diet. | |
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MedLine Citation:
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PMID: 20921276 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Soy diet ameliorates renal injury in the Han:SPRD-cy rat. The relative roles of protein, isoflavones and changes in polyunsaturated fatty acid (PUFA) status are not determined. We fed male Han:SPRD-cy heterozygotes casein (C), high isoflavone soy protein (HIS), alcohol-extracted low isoflavone soy protein (LIS) or mixed soy protein diet (MIS). LIS and MIS were associated with a small decrease in animal weight compared with HIS or C. Soy diets preserved normal renal function and reduced relative renal weight (10.9-14.6 g/kg, cf. 23.6, P < 0.001), scores for cystic change (0.168-0.239, cf. 0.386, P < 0.05), fibrosis (0.013-0.015, cf. 0.032, P < 0.05), tissue oxidized LDL content (0.012-0.021, cf. 0.048, P < 0.05), inflammation (8.5-12.9, cf. 31.2, P < 0.05) and epithelial cell proliferation (6.5-13.8, cf. 26.3, P < 0.05). In post hoc testing, LIS produced a greater reduction in relative renal weight, cystic change and epithelial proliferation, whereas HIS produced a significantly greater reduction in oxidized-LDL. Soy diets were associated with increased hepatic content of 18C PUFA (P < 0.001). LIS and HIS diets were associated with a small increase in body fat content (P < 0.001). Alcohol-extracted soy protein retains its major protective effects in this model with subtle differences attributable to isoflavones. |
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Authors:
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Malcolm R Ogborn; Evan Nitschmann; Neda Bankovic-Calic; Hope A Weiler; Harold M Aukema |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-04 |
Journal Detail:
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Title: Experimental biology and medicine (Maywood, N.J.) Volume: 235 ISSN: 1535-3699 ISO Abbreviation: Exp. Biol. Med. (Maywood) Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-26 Completed Date: 2010-12-03 Revised Date: 2011-03-11 |
Medline Journal Info:
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Nlm Unique ID: 100973463 Medline TA: Exp Biol Med (Maywood) Country: England |
Other Details:
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Languages: eng Pagination: 1315-20 Citation Subset: IM |
Affiliation:
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Department of Pediatrics and Child Health, University of Manitoba, Winnipeg. ogborn@unbc.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Caseins / chemistry, pharmacology Cell Proliferation / drug effects Cholesterol, LDL / metabolism Dietary Proteins / pharmacology* Disease Models, Animal Isoflavones Male Organ Size Oxidation-Reduction Polycystic Kidney Diseases / diet therapy*, pathology Rats Rats, Inbred Strains Soybean Proteins / chemistry, pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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//Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
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0/Caseins; 0/Cholesterol, LDL; 0/Dietary Proteins; 0/Isoflavones; 0/Soybean Proteins |
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