Document Detail

Dietary sources of vitamin B-12 and their association with plasma vitamin B-12 concentrations in the general population: the Hordaland Homocysteine Study.
MedLine Citation:
PMID:  19190073     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Limited information is available on the association between vitamin B-12 status and intake from different dietary sources. OBJECTIVE: We investigated the relation of dietary intake of different food items with plasma vitamin B-12 concentrations in the general population. DESIGN: A cross-sectional, population-based study of 5937 subjects in 2 age groups (47-49 and 71-74 y) from the Hordaland Homocysteine Study in Norway was conducted by using a food-frequency questionnaire and measurements of plasma vitamin B-12 concentrations. RESULTS: A significant difference in plasma vitamin B-12 concentrations was observed with increasing total vitamin B-12 intake. A plateau was reached at an intake of approximately 10 microg/d. Plasma vitamin B-12 was associated with intakes of increasing amounts of vitamin B-12 from dairy products or fish (P for trend <0.001 for both) but not with intakes of vitamin B-12 from meat or eggs. For the same content of vitamin B-12, intake from dairy products led to the greatest increase in plasma vitamin B-12. Total intake of vitamin B-12, particularly from milk and fish, decreased the risk of vitamin B-12 concentrations <200 pmol/L and impaired vitamin B-12 function (vitamin B-12 <200 pmol/L and methylmalonic acid >0.27 micromol/L) in the total group and in 71-74-y-old subjects. CONCLUSIONS: Dietary intake of dairy products and fish are significant contributors to plasma vitamin B-12 and may improve plasma vitamin B-12 status. Vitamin B-12 appears to be more bioavailable from dairy products; guidelines for improving vitamin B-12 status should take this into consideration.
Anna Vogiatzoglou; A David Smith; Eha Nurk; Paula Berstad; Christian A Drevon; Per M Ueland; Stein E Vollset; Grethe S Tell; Helga Refsum
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-03
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  89     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-19     Completed Date:  2009-04-06     Revised Date:  2009-05-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1078-87     Citation Subset:  AIM; IM    
OPTIMA, Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, UK.
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MeSH Terms
Aging / blood,  physiology
Biological Availability
Cross-Sectional Studies
Dairy Products
Diet Surveys
Homocysteine / blood*
Middle Aged
Norway / epidemiology
Nutritional Requirements
Nutritional Status*
Vitamin B 12 / administration & dosage*,  blood*,  pharmacokinetics
Vitamin B 12 Deficiency / epidemiology,  prevention & control
Vitamin B Complex / administration & dosage,  blood,  pharmacokinetics
Reg. No./Substance:
12001-76-2/Vitamin B Complex; 454-28-4/Homocysteine; 68-19-9/Vitamin B 12

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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