| Dietary sources of lignans and isoflavones modulate responses to estradiol in estrogen reporter mice. | |
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MedLine Citation:
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PMID: 19603405 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dietary phytoestrogens, such as the lignan metabolite enterolactone (ENL) and the isoflavone genistein (GEN), are suggested to modulate the risk of estrogen-dependent disease (e.g., breast cancer) through regulation of estrogen signaling. However, the effects of complex food items containing lignans or isoflavones on estrogen receptor (ER) transactivation have not been assessed so far. In this study, the modulation of ER-mediated signaling by dietary sources of lignans (cereals and flaxseed) and isoflavones (soy) was studied in vivo. Adult ovariectomized 3 x ERE-luciferase (luc) reporter mice received isocaloric diets supplemented with flaxseed, rye, wheat, or soy for 40 h or two weeks, and an additional group of mice was challenged with 17beta-estradiol (E(2)) following the two-week dietary intervention. In non-E(2)-treated mice, soy diet induced luc expression in liver, mammary gland, and pituitary gland while the other diets had no effects. Interestingly, all diets modulated the E(2)-induced luc expression. In particular rye diet efficiently reduced E(2)-induced luc expression as well as uterine growth, the hallmark of estrogen action in vivo. It is concluded that dietary sources of lignans and isoflavones can modulate estrogen signaling in vivo. The results suggest intriguing possibilities for the modulation of the risk of estrogen-dependent diseases by dietary means. |
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Authors:
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Pauliina E Penttinen-Damdimopoulou; Krista A Power; Teija T Hurmerinta; Tarja Nurmi; Paul T van der Saag; Sari I Mäkelä |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Molecular nutrition & food research Volume: 53 ISSN: 1613-4133 ISO Abbreviation: Mol Nutr Food Res Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-08-03 Completed Date: 2009-10-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101231818 Medline TA: Mol Nutr Food Res Country: Germany |
Other Details:
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Languages: eng Pagination: 996-1006 Citation Subset: IM |
Affiliation:
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Functional Foods Forum, University of Turku, FI-20014 Turku, Finland. pauliina@watchfrog.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cereals Diet* Estradiol / pharmacology* Female Flax Isoflavones / pharmacology* Lignans / pharmacology* Luciferases / genetics Mice Receptors, Estrogen / physiology Weight Gain |
| Chemical | |
Reg. No./Substance:
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0/Isoflavones; 0/Lignans; 0/Receptors, Estrogen; 50-28-2/Estradiol; EC 1.13.12.-/Luciferases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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