Document Detail

Dietary sodium intake modulates vasodilation mediated by nitroprusside but not by methacholine in the human forearm.
MedLine Citation:
PMID:  7768565     Owner:  NLM     Status:  MEDLINE    
Studies in animals suggest that nitric oxide production is increased under conditions of salt loading and that this increase protects against the development of salt-induced hypertension. To determine the effect of dietary sodium intake on nitric oxide-mediated vascular responses, we studied seven healthy male volunteers twice 4 weeks apart while they were receiving a diet containing 10 or 250 mmol Na+ per 24 hours. Methacholine (0.25 to 8 micrograms/min) and sodium nitroprusside (0.25 to 8 micrograms/min) were infused intra-arterially in incremental doses, and forearm blood flow was measured. The response of forearm blood flow to sodium nitroprusside was greater when subjects received a high sodium diet than when they received a low sodium diet (F = 7.11, P < .05); however, the response to methacholine was not altered by sodium intake (F = 0.57, P = NS). Plasma renin activity was significantly higher (3.99 versus 1.0 ng angiotensin I/mL per hour) when subjects received a low salt diet (P < .05). Systolic pressure, diastolic pressure, heart rate, and baseline forearm blood flow were not affected by sodium status. We conclude that under conditions of salt loading, vasodilation in response to sodium nitroprusside was enhanced, whereas the response to methacholine was not affected, suggesting a differential effect of sodium intake on endothelium-dependent and endothelium-independent responses after the administration of methacholine and sodium nitroprusside, respectively.
C M Stein; R Nelson; M Brown; M Wood; A J Wood
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  25     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-06-30     Completed Date:  1995-06-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1220-3     Citation Subset:  IM    
Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232-6602, USA.
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MeSH Terms
Forearm / blood supply
Methacholine Chloride / pharmacology*
Nitric Oxide / biosynthesis
Nitroprusside / pharmacology*
Norepinephrine / blood
Regional Blood Flow / drug effects
Renin / blood
Sodium, Dietary / administration & dosage*
Vasodilation / drug effects*
Grant Support
Reg. No./Substance:
0/Sodium, Dietary; 10102-43-9/Nitric Oxide; 15078-28-1/Nitroprusside; 51-41-2/Norepinephrine; 62-51-1/Methacholine Chloride; EC

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