Document Detail

Dietary sodium and blood pressure: interactions with other nutrients.
MedLine Citation:
PMID:  9022570     Owner:  NLM     Status:  MEDLINE    
This paper reviews the evidence that salt sensitivity of blood pressure is related both to the anion ingested with sodium as well as to other components of the diet. In several experimental models of salt-sensitive hypertension and in humans, blood pressure is not increased by a high sodium intake provided with anions other than chloride. Salt-induced increase of blood pressure depends on the concomitant ingestion of both sodium and chloride. Both epidemiologic and clinical evidence suggest that sodium chloride-induced increases of blood pressure are augmented by diets deficient in potassium or calcium. In experimental animals, a high intake of simple carbohydrates also augments sodium chloride sensitivity of blood pressure. These observations indicate that the effect of dietary sodium on blood pressure is modulated by other components of the diet.
T A Kotchen; J M Kotchen
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  65     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-02-26     Completed Date:  1997-02-26     Revised Date:  2013-04-04    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  708S-711S     Citation Subset:  AIM; IM    
Department of Medicine, Medical College of Wisconsin, Milwaukee 53226, USA.
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MeSH Terms
Blood Pressure / drug effects*
Citrates / pharmacology
Dietary Sucrose / administration & dosage,  pharmacology
Hypertension / etiology*
Potassium, Dietary / administration & dosage
Sodium Bicarbonate / pharmacology
Sodium Chloride, Dietary / adverse effects*
Sodium, Dietary / administration & dosage*,  adverse effects
Reg. No./Substance:
0/Citrates; 0/Dietary Sucrose; 0/Potassium, Dietary; 0/Sodium Chloride, Dietary; 0/Sodium, Dietary; 144-55-8/Sodium Bicarbonate; 1Q73Q2JULR/sodium citrate

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