Document Detail


Dietary sodium alters the prevalence of electrocardiogram determined left ventricular hypertrophy in hypertension.
MedLine Citation:
PMID:  19265788     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Determination of left ventricular hypertrophy (LVH) via electrocardiogram (ECG) is a known independent risk factor for cardiovascular morbidity and mortality in hypertension (HTN). Dietary sodium and HTN are both associated with unfavorable alterations in left ventricular mass, however, to what extent their interplay affects ECG screening for LVH is unclear.
METHODS: The effects of controlled dietary sodium manipulation on ECG determinants of LVH in hypertensive subjects were evaluated using well-established voltage criteria for LVH. ECGs from 80 hypertensive subjects were evaluated following random sequence assignment to 7 days of high sodium (HS) intake (200 mEq/24 h), and then 7 days of low sodium (LS) intake (10 mEq/24 h).
RESULTS: Sodium restriction over 7 days resulted in significant decreases in overall, and LVH-specific, ECG voltages. Most subjects exhibited decrements in overall ECG voltage with sodium restriction (72%); however, a smaller subset displayed higher voltages when on LS intake (28%). The prevalence of ECG-determined LVH was significantly lowered with LS diet (HS diet 22/80 (28%) vs. LS diet 8/80 (10%), P < 0.05). Subjects exhibiting reversal of LVH status with sodium restriction were younger, demonstrated salt sensitivity of blood pressure, and lower LVH-specific ECG voltage.
CONCLUSIONS: Short-term dietary sodium fluctuations can significantly alter overall ECG voltage and the prevalence of ECG-determined LVH in hypertensive individuals. Inclusion of dietary sodium assessment when screening hypertensive subjects for LVH by ECG may improve the consistency of cardiac risk assessment.
Authors:
Anand Vaidya; Rhonda Bentley-Lewis; Xavier Jeunemaitre; Gail K Adler; Jonathan S Williams
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2009-03-05
Journal Detail:
Title:  American journal of hypertension     Volume:  22     ISSN:  1941-7225     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-20     Completed Date:  2009-06-23     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  669-73     Citation Subset:  IM    
Affiliation:
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. avaidya1@partners.org
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MeSH Terms
Descriptor/Qualifier:
Blood Pressure / drug effects*
Diet, Sodium-Restricted
Electrocardiography / drug effects*
Female
Follow-Up Studies
Humans
Hypertension / complications,  diet therapy*,  physiopathology
Hypertrophy, Left Ventricular / epidemiology*,  etiology,  physiopathology
Male
Middle Aged
Prevalence
Prognosis
Risk Factors
Sodium, Dietary / pharmacology*
Grant Support
ID/Acronym/Agency:
DK63214/DK/NIDDK NIH HHS; HL47651/HL/NHLBI NIH HHS; HL55000/HL/NHLBI NIH HHS; HL59424/HL/NHLBI NIH HHS; HL77234/HL/NHLBI NIH HHS; K23 HL084236/HL/NHLBI NIH HHS; K23 HL084236/HL/NHLBI NIH HHS; K23 HL084236-03/HL/NHLBI NIH HHS; K23 RR023333/RR/NCRR NIH HHS; K23 RR023333/RR/NCRR NIH HHS; K23 RR023333-02/RR/NCRR NIH HHS; L32 MD001077/MD/NIMHD NIH HHS; L32 MD001077-03/MD/NIMHD NIH HHS; M01 RR 02635/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Sodium, Dietary
Comments/Corrections

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