Document Detail


Dietary sialic acid supplementation improves learning and memory in piglets.
MedLine Citation:
PMID:  17284758     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Sialic acid, a key component of both human milk oligosaccharides and neural tissues, may be a conditional nutrient during periods of rapid brain growth. OBJECTIVE: We tested the hypothesis that variations in the sialic acid content of a formula milk would influence early learning behavior and gene expression of enzymes involved in sialic acid metabolism in piglets. DESIGN: Piglets (n = 54) were allocated to 1 of 4 groups fed sow milk replacer supplemented with increasing amounts of sialic acid as casein glycomacropeptide for 35 d. Learning performance and memory were assessed with the use of easy and difficult visual cues in an 8-arm radial maze. Brain ganglioside and sialoprotein concentrations and mRNA expression of 2 learning-associated genes (ST8SIA4 and GNE) were measured. RESULTS: In both tests, the supplemented groups learned in significantly fewer trials than did the control group, with a dose-response relation for the difficult task (P = 0.018) but not the easy task. In the hippocampus, significant dose-response relations were observed between amount of sialic acid supplementation and mRNA levels of ST8SIA4 (P = 0.002) and GNE (P = 0.004), corresponding with proportionate increases in protein-bound sialic acid concentrations in the frontal cortex. CONCLUSIONS: Feeding a protein-bound source of sialic acid during early development enhanced learning and increased expression of 2 genes associated with learning in developing piglets. Sialic acid in mammalian milks could play a role in cognitive development.
Authors:
Bing Wang; Bing Yu; Muhsin Karim; Honghua Hu; Yun Sun; Paul McGreevy; Peter Petocz; Suzanne Held; Jennie Brand-Miller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  85     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-07     Completed Date:  2007-03-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  561-9     Citation Subset:  AIM; IM    
Affiliation:
Human Nutrition Unit, School of Molecular and Microbial Biosciences, University of Sydney, Sydney, NWS, Australia.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / metabolism
Animal Feed
Animal Nutritional Physiological Phenomena
Animals
Body Weight
Dietary Supplements*
Hydrocortisone / metabolism
Learning / drug effects*
Male
Memory / drug effects*
Multienzyme Complexes / metabolism
N-Acetylneuraminic Acid / administration & dosage*,  pharmacology*
Sialyltransferases / metabolism
Swine*
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Multienzyme Complexes; 0/UDP-N-acetylglucosamine 2-epimerase - N-acetylmannosamine kinase; 131-48-6/N-Acetylneuraminic Acid; 50-23-7/Hydrocortisone; EC 2.4.99.-/Sialyltransferases; EC 3.4.99.-/ST8Sia IV protein, swine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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