Document Detail

Dietary selenium- and vitamin E-induced alterations in some rabbit tissues.
MedLine Citation:
PMID:  9403135     Owner:  NLM     Status:  MEDLINE    
The present study was designed to investigate and compare the effects of dietary selenium (Se) and vitamin E on some physiological parameters and histological changes in liver, heart, and skin tissues, as well as the blood parameters and the related enzymes. Both sex young rabbits were fed with deficient (9.8 micrograms/kg diet), adequate (225 micrograms/kg diet), and rich (4.2 mg/kg diet) Se and vitamin E diets for 12-15 wk for this purpose. As the plasma Se levels and the erythrocyte glutathione (GSH) peroxidase activity decreased (79.8 +/- 9.4 ng/mL and 2.0 +/- 0.3 U/g Hb, respectively) in the deficient group, these values increased (100.4 +/- 2.7 ng/mL and 14.5 +/- 4.3 U/g Hb) in the rich group significantly with respect to the control group. The other antioxidant enzyme activities and the related element levels did not change significantly in either one of the experimental groups. Although the platelet counts of the two experimental groups were not different from the control values, the collagen and the adenosine diphosphate (ADP) stimulated platelet aggregation rate and intensity increased in the deficient group (p < 0.05) and decreased very significantly (p < 0.001) in the rich group. In both of the experimental groups, as the percentage values of the neutrophils decreased, the lymphocytes and the eosinophils increased significantly. According to the light microscopic investigations, the observed lesions of considerable intensity within the tissues that elicit cell degenerations were more pronounced in the animals fed with the rich diet than in those fed with the deficient diet. The deficiency as well as toxicity of Se and the deficiency of vitamin E caused several alterations in the physiological functions of the tissues, and these alterations were supported by the histological lesions within these tissues.
B Turan; N Zaloglu; E Koc; Y Saran; N Akkas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological trace element research     Volume:  58     ISSN:  0163-4984     ISO Abbreviation:  Biol Trace Elem Res     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1998-01-07     Completed Date:  1998-01-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7911509     Medline TA:  Biol Trace Elem Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  237-53     Citation Subset:  IM    
Department of Biophysics, Faculty of Medicine Ankara University, Turkey.
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MeSH Terms
Blood Platelets / drug effects,  physiology
Glutathione Peroxidase / blood
Heart / drug effects,  physiology
Liver / drug effects,  physiology
Selenium / administration & dosage,  blood,  deficiency,  pharmacology*
Skin Physiological Phenomena / drug effects
Vitamin E / administration & dosage,  pharmacology*
Vitamin E Deficiency / blood,  physiopathology
Reg. No./Substance:
1406-18-4/Vitamin E; 7782-49-2/Selenium; EC Peroxidase

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