| Dietary selenium requirements based on tissue selenium concentration and glutathione peroxidase activities in old female rats. | |
| | |
MedLine Citation:
|
PMID: 19398061 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Dietary nutrient requirements for older animals have been studied far less than have requirements for young growing animals. To determine dietary selenium (Se) requirements in old rats, we fed female weanling rats a Se-deficient diet (0.007 microg Se/g) or supplemented rats with graded levels of dietary Se (0-0.3 microg Se/g) as Na(2)SeO(3) for 52 weeks. At no point did Se deficiency or level of Se supplementation have a significant effect (P>0.05) on growth. To determine Se requirements, Se response curves were determined for 7 Se-dependent parameters. We found that minimum dietary Se requirements in year-old female rats were at or below 0.05 microg Se/g diet based on liver Se, red blood cell glutathione peroxidase (Gpx1) activity, plasma Gpx3 activity, liver and kidney Gpx1 activity, and liver and kidney Gpx4 activity. In conclusion, this study found that dietary Se requirements in old female rats were decreased at least 50% relative to requirements found in young, rapidly growing female rats. Collectively, this indicates that the homeostatic mechanisms related to retention and maintenance of Se status are still fully functional in old female rats. |
| | |
Authors:
|
Roger A Sunde; Kevin M Thompson |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-03-14 |
Journal Detail:
|
Title: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) Volume: 23 ISSN: 1878-3252 ISO Abbreviation: J Trace Elem Med Biol Publication Date: 2009 |
Date Detail:
|
Created Date: 2009-04-28 Completed Date: 2009-07-09 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9508274 Medline TA: J Trace Elem Med Biol Country: Germany |
Other Details:
|
Languages: eng Pagination: 132-7 Citation Subset: IM |
Affiliation:
|
Department of Nutritional Sciences, University of Wisconsin, Madison, WI 53706, USA. sunde@nutrisci.wisc.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Female Glutathione Peroxidase / metabolism* Nutritional Requirements* Pregnancy Rats Selenium / administration & dosage, metabolism* Trace Elements / administration & dosage, metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Trace Elements; 7782-49-2/Selenium; EC 1.11.1.-/GPX3 protein, rat; EC 1.11.1.-/glutathione peroxidase GPX1; EC 1.11.1.9/Glutathione Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Differential quantitative zinc-induced expression of human metallothionein isogenes in haematopoieti...
Next Document: Acute high-dose sodium selenite administration improves intestinal microcirculation without affectin...