| Dietary selenium intake influences Cx43 dephosphorylation, TNF-α expression and cardiac remodeling after reperfused infarction. | |
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MedLine Citation:
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PMID: 21462319 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Scope: Post-infarct left ventricular dysfunction and cardiac remodeling are the primary causes of chronic heart failure in industrialized countries. In the present study, we examined the influence of dietary selenium intake on cardiac remodeling after reperfused myocardial infarction and explored one of the possible mechanisms. Methods and results: Rats were fed a diet containing either 0.05 mg/kg (Low-Se, group of rats receiving the low-selenium diet) or 1.50 mg/kg (group of rats receiving the high-selenium diet) selenium. At the end of the 5th week of the diet, rats were subjected to transient (1 h) coronary ligation followed by 8 days of reperfusion. Infarct size and cardiac passive compliance were increased in the Low-Se group compared with group of rats receiving the high-selenium diet. Similarly, indices of cardiac remodeling (thinning index and expansion index) were more altered in Low-Se hearts. These adverse effects of the Low-Se diet on cardiac remodeling were accompanied by an increase in cardiac TNF-α content, a decreased activity of antioxidant seleno-enzymes and an increase in connexin-43 dephosphorylation. Conclusion: Dietary selenium intake influences post-infarct cardiac remodeling even when provided within the range of physiological values. Our data suggest that the cardioprotective effect of selenium might be mediated by a reduced oxidative stress, a lower connexin-43 dephosphorylation, and a decreased TNF-α expression. |
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Authors:
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Stéphane Tanguy; Andry Rakotovao; Marie-Gabrielle Jouan; Catherine Ghezzi; Joël de Leiris; François Boucher |
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Publication Detail:
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Type: Journal Article Date: 2010-12-15 |
Journal Detail:
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Title: Molecular nutrition & food research Volume: 55 ISSN: 1613-4133 ISO Abbreviation: Mol Nutr Food Res Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101231818 Medline TA: Mol Nutr Food Res Country: Germany |
Other Details:
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Languages: eng Pagination: 522-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Laboratoire TIMC-IMAG, UMR 5525 CNRS - University of Grenoble, Grenoble, France; EA-4278, Université d'Avignon et des Pays de Vaucluse, UFR Sciences, Avignon, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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