Document Detail

Dietary selenium, hepatic arylhydrocarbon hydroxylase and mutagenic activation of benzo(a)pyrene, 2-aminoanthracene and 2-aminofluorene.
MedLine Citation:
PMID:  6285555     Owner:  NLM     Status:  MEDLINE    
The effect of dietary selenium (Se) on the hepatic aryl hydrocarbon hydroxylase (AHH) and mutagenic activation potential in young and adult rats was investigated. Animals were maintained on a low Se basal diet with or without 1 or 2 ppm Se supplementation (as sodium selenite) for 5 or 20 weeks. AHH inducibility was determined by an intraperitoneal injection of Aroclor 5 days prior to killing. A significant reduction in the AHH level was observed in low Se group of young untreated rats only. Dietary Se did not affect AHH inducibility by Aroclor treatment and the induced AHH levels were similar in both dietary groups. 5 weeks on low dietary Se did not alter the AHH levels in untreated or treated adult rats. The levels of Se-dependent glutathione peroxidase (GSH-P) were decreased more drastically in the young than adult rats by low dietary Se. Studies on the metabolic activation potential of liver enzymes from young rats on basal and Se-supplemented diets showed that dietary Se did not alter the activation of benzo(a)pyrene (BP) to mutagens although differences in the activation of 2-aminofluorene (2AF) and 2-aminoanthracene (2AA) were observed.
C Gairola; C K Chow
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Toxicology letters     Volume:  11     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  1982 May 
Date Detail:
Created Date:  1982-09-17     Completed Date:  1982-09-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  281-7     Citation Subset:  IM    
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MeSH Terms
Anthracenes / metabolism,  toxicity
Aroclors / pharmacology
Aryl Hydrocarbon Hydroxylases / metabolism*
Benzopyrenes / metabolism,  toxicity
Biotransformation / drug effects
Chlorodiphenyl (54% Chlorine)
Cytochrome P-450 Enzyme System / metabolism
Fluorenes / metabolism,  toxicity
Liver / enzymology*
Mutagens / metabolism*
Rats, Inbred Strains
Selenium / pharmacology*
Reg. No./Substance:
0/Anthracenes; 0/Aroclors; 0/Benzopyrenes; 0/Fluorenes; 0/Mutagens; 11097-69-1/Chlorodiphenyl (54% Chlorine); 153-78-6/2-aminofluorene; 50-32-8/Benzo(a)pyrene; 613-13-8/2-anthramine; 7782-49-2/Selenium; 9035-51-2/Cytochrome P-450 Enzyme System; EC Hydrocarbon Hydroxylases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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