| Dietary selenium affects host selenoproteome expression by influencing the gut microbiota. | |
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MedLine Citation:
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PMID: 21493887 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Colonization of the gastrointestinal tract and composition of the microbiota may be influenced by components of the diet, including trace elements. To understand how selenium regulates the intestinal microflora, we used high-throughput sequencing to examine the composition of gut microbiota of mice maintained on selenium-deficient, selenium-sufficient, and selenium-enriched diets. The microbiota diversity increased as a result of selenium in the diet. Specific phylotypes showed differential effects of selenium, even within a genus, implying that selenium had unique effects across microbial taxa. Conventionalized germ-free mice subjected to selenium diets gave similar results and showed an increased diversity of the bacterial population in animals fed with higher levels of selenium. Germ-free mice fed selenium diets modified their selenoproteome expression similar to control mice but showed higher levels and activity of glutathione peroxidase 1 and methionine-R-sulfoxide reductase 1 in the liver, suggesting partial sequestration of selenium by the gut microorganisms, limiting its availability for the host. These changes in the selenium status were independent of the levels of other trace elements. The data show that dietary selenium affects both composition of the intestinal microflora and colonization of the gastrointestinal tract, which, in turn, influence the host selenium status and selenoproteome expression. |
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Authors:
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Marina V Kasaikina; Marina A Kravtsova; Byung Cheon Lee; Javier Seravalli; Daniel A Peterson; Jens Walter; Ryan Legge; Andrew K Benson; Dolph L Hatfield; Vadim N Gladyshev |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural Date: 2011-04-14 |
Journal Detail:
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Title: FASEB journal : official publication of the Federation of American Societies for Experimental Biology Volume: 25 ISSN: 1530-6860 ISO Abbreviation: FASEB J. Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-07-01 Completed Date: 2011-09-28 Revised Date: 2012-02-15 |
Medline Journal Info:
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Nlm Unique ID: 8804484 Medline TA: FASEB J Country: United States |
Other Details:
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Languages: eng Pagination: 2492-9 Citation Subset: IM |
Affiliation:
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Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blotting, Western Dietary Supplements Feces / microbiology Gastrointestinal Tract / drug effects*, metabolism, microbiology Gene Expression / drug effects* Germ-Free Life Glutathione Peroxidase / metabolism Intestines / drug effects, metabolism, microbiology Male Metagenome / genetics Methionine Sulfoxide Reductases / metabolism Mice Mice, Inbred C57BL Proteome / genetics*, metabolism Reverse Transcriptase Polymerase Chain Reaction Selenium / administration & dosage, pharmacology* Selenoproteins / blood, genetics*, metabolism Sequence Analysis, DNA Trace Elements / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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AG021518/AG/NIA NIH HHS; GM061603/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Proteome; 0/Selenoproteins; 0/Trace Elements; 7782-49-2/Selenium; EC 1.11.1.-/glutathione peroxidase GPX1; EC 1.11.1.9/Glutathione Peroxidase; EC 1.8.4.-/Methionine Sulfoxide Reductases; EC 1.8.4.6/methionine sulfoxide reductase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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