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Dietary salt intake is related to inflammation and albuminuria in primary hypertensive patients.
MedLine Citation:
PMID:  22909578     Owner:  NLM     Status:  Publisher    
BACKGROUND/OBJECTIVES:In this study, we hypothesized that dietary salt intake may be related with inflammation and albuminuria independently from blood pressure (BP) in non-diabetic hypertensive patients.SUBJECTS/METHODS:A total of 224 patients with primary hypertension were included in the study. Serum C-reactive protein (CRP) levels, 24-h urine sodium and albumin excretion were measured in all patients. The subjects were divided into tertiles according to the level of 24-h urinary sodium excretion: low-salt-intake group (n=76, mean urine sodium: 111.7±29.1 mmol/24 h), medium-salt-intake group (n=77, mean urine sodium: 166.1±16.3 mmol/24 h) and high-salt-intake group (n=71, mean urine sodium: 263.6±68.3 mmol/24 h).RESULTS:Systolic and diastolic BP measurements of patients were similar in the three salt-intake groups. CRP and urinary albumin levels were significantly higher in high-salt-intake group compared with medium- and low-salt-intake groups (P=0.0003 and P=0.001, respectively). CRP was positively correlated with 24-h urinary sodium excretion (r=0.28, P=0.0008) and albuminuria, whereas albuminuria was positively correlated with 24-h urinary sodium excretion (r=0.21, P=0.0002). Multiple regression analysis revealed that urinary sodium excretion was an independent predictor of both CRP and albuminuria.CONCLUSIONS:These findings suggest that high salt intake is associated with enhanced inflammation and target organ damage reflected by increased albuminuria in treated hypertensive patients independent of any BP effect.European Journal of Clinical Nutrition advance online publication, 22 August 2012; doi:10.1038/ejcn.2012.110.
R Yilmaz; H Akoglu; B Altun; T Yildirim; M Arici; Y Erdem
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-22
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  -     ISSN:  1476-5640     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
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