| Dietary restriction enhances germline stem cell maintenance. | |
| | |
MedLine Citation:
|
PMID: 20569233 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Dietary restriction (DR) increases lifespan in species ranging from yeast to primates, maintaining tissues in a youthful state and delaying reproductive senescence. However, little is known about the mechanisms by which this occurs. Here we demonstrate that, concurrent with extending lifespan, DR attenuates the age-related decline in male germline stem cell (GSC) number in Drosophila. These data support a model whereby DR enhances maintenance of GSCs to extend the reproductive period of animals subjected to adverse nutritional conditions. This represents the first example of DR maintaining an adult stem cell pool and suggests a potential mechanism by which DR might delay aging in the tissues of higher organisms. |
| | |
Authors:
|
William Mair; Catherine J McLeod; Lei Wang; D Leanne Jones |
Related Documents
:
|
11994503 - Activation-induced expression of mica on t lymphocytes involves engagement of cd3 and c... 2947883 - Dissection of suppressor cell generation in vitro. 3950753 - Cerebrospinal fluid rhinorrhea following surgery for acoustic neurinoma. report of two ... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Aging cell Volume: 9 ISSN: 1474-9726 ISO Abbreviation: Aging Cell Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-22 Completed Date: 2011-02-04 Revised Date: 2012-05-07 |
Medline Journal Info:
|
Nlm Unique ID: 101130839 Medline TA: Aging Cell Country: England |
Other Details:
|
Languages: eng Pagination: 916-8 Citation Subset: IM |
Copyright Information:
|
© 2010 The Authors Aging Cell © 2010 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland. |
Affiliation:
|
The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Caloric Restriction Cell Aging / physiology Cell Count Drosophila melanogaster / cytology*, physiology Food Deprivation / physiology* Longevity / physiology Male Reproduction / physiology Spermatogonia / cytology* Stem Cells / cytology* |
| Grant Support | |
ID/Acronym/Agency:
|
R01 AG028092-04/AG/NIA NIH HHS; R01 AG028092-05/AG/NIA NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Peer substance involvement modifies genetic influences on regular substance involvement in young wom...
Next Document: BTG2 antagonizes Pin1 in response to mitogens and telomere disruption during replicative senescence.