Document Detail

Dietary quercetin supplementation is not ergogenic in untrained men.
MedLine Citation:
PMID:  19679747     Owner:  NLM     Status:  MEDLINE    
Quercetin supplementation increases muscle oxidative capacity and endurance in mice, but its ergogenic effect in humans has not been established. Our study investigates the effects of short-duration chronic quercetin supplementation on muscle oxidative capacity; metabolic, perceptual, and neuromuscular determinants of performance in prolonged exercise; and cycling performance in untrained men. Using a double-blind, pretest-posttest control group design, 30 recreationally active, but not endurance-trained, young men were randomly assigned to quercetin and placebo groups. A noninvasive measure of muscle oxidative capacity (phosphocreatine recovery rate using magnetic resonance spectroscopy), peak oxygen uptake (Vo(2peak)), metabolic and perceptual responses to submaximal exercise, work performed on a 10-min maximal-effort cycling test following the submaximal cycling, and voluntary and electrically evoked strength loss following cycling were measured before and after 7-16 days of supplementation with 1 g/day of quercetin in a sports hydration beverage or a placebo beverage. Pretreatment-to-posttreatment changes in phosphocreatine recovery time constant, Vo(2peak,) substrate utilization, and perception of effort during submaximal exercise, total work done during the 10-min maximal effort cycling trial, and voluntary and electrically evoked strength loss were not significantly different (P > 0.05) in the quercetin and placebo groups. Short duration, chronic dietary quercetin supplementation in untrained men does not improve muscle oxidative capacity; metabolic, neuromuscular and perceptual determinants of performance in prolonged exercise; or cycling performance. The null findings indicate that metabolic and physical performance consequences of quercetin supplementation observed in mice should not be generalized to humans.
Kirk J Cureton; Phillip D Tomporowski; Arpit Singhal; Jeffrey D Pasley; Kevin A Bigelman; Kathleen Lambourne; Jennifer L Trilk; Kevin K McCully; Maurice J Arnaud; Qun Zhao
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2009-08-13
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  107     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-16     Completed Date:  2009-12-24     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1095-104     Citation Subset:  IM    
Department of Kinesiology, Ramsey Center, 330 River Road, Univ. of Georgia Athens, GA 30602-6554.
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MeSH Terms
3-Hydroxybutyric Acid / blood
Administration, Oral
Biological Markers / blood
Blood Glucose / drug effects
Cross-Over Studies
Dietary Supplements*
Double-Blind Method
Electric Stimulation
Energy Metabolism / drug effects*
Fatty Acids, Nonesterified / blood
Glycerol / blood
Magnetic Resonance Spectroscopy
Muscle Contraction / drug effects*
Muscle Strength / drug effects
Muscle, Skeletal / drug effects*,  metabolism
Oxygen Consumption / drug effects
Phosphocreatine / blood
Quercetin / administration & dosage*,  blood
Time Factors
Young Adult
Reg. No./Substance:
0/Biological Markers; 0/Blood Glucose; 0/Fatty Acids, Nonesterified; 117-39-5/Quercetin; 300-85-6/3-Hydroxybutyric Acid; 56-81-5/Glycerol; 67-07-2/Phosphocreatine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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