Document Detail

Dietary protein and soluble fiber reduce ambulatory blood pressure in treated hypertensives.
MedLine Citation:
PMID:  11641293     Owner:  NLM     Status:  MEDLINE    
In population studies, higher blood pressure has been associated with lower intake of protein and, possibly, lower fiber consumption. In the present randomized controlled trial, we sought to determine whether dietary protein and fiber had additive effects on blood pressure reduction in hypertensives. Treated hypertensive patients changed for 4 weeks (familiarization) to a diet low in protein (12.5% energy) and fiber (15 g/d). Patients (n=41) were then randomized to 1 of 4 groups in an 8-week factorial study of parallel design in which they continued the low-protein, low-fiber diet alone or had supplements of soy protein to increase protein intake to 25% energy, of psyllium to provide an additional 12 g soluble fiber/d, or of both protein and fiber. The 24-hour ambulatory blood pressure was compared from the end of familiarization to the end of intervention. In the 36 subjects who provided complete data, protein and fiber had significant additive effects to lower 24-hour and awake systolic blood pressure. Relative to control subjects, the net reduction in 24-hour systolic blood pressure was 5.9 mm Hg with fiber and with protein. Findings were independent of age, gender, and change in weight, alcohol intake, or urinary sodium and potassium. Relative to reduced fiber and protein intake, dietary protein and soluble fiber supplements lower blood pressure additively in hypertensives. These findings have important implications for the prevention and management of hypertension, particularly in populations in which high blood pressure is prevalent in association with diets low in protein, fiber, or both.
V Burke; J M Hodgson; L J Beilin; N Giangiulioi; P Rogers; I B Puddey
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hypertension     Volume:  38     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-19     Completed Date:  2001-11-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  821-6     Citation Subset:  IM    
Department of Medicine, University of Western Australia, Royal Perth Hospital and West Australian Heart Research Institute, Perth, Australia.
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MeSH Terms
Blood Pressure / drug effects*
Blood Pressure Monitoring, Ambulatory
Body Weight / drug effects
Dietary Fiber / administration & dosage*
Dietary Proteins / administration & dosage*
Heart Rate / drug effects
Hypertension / physiopathology,  therapy*
Middle Aged
Treatment Outcome
Urea / urine
Reg. No./Substance:
0/Dietary Proteins; 57-13-6/Urea

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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