Document Detail

Dietary protein-induced colitis in breast-fed infants.
MedLine Citation:
PMID:  7143166     Owner:  NLM     Status:  MEDLINE    
Six infants are reported who developed an inflammatory proctocolitis in the first month of life while being breast fed exclusively. All has been born at term and had normal perinatal courses. None had growth failure or constitutional symptoms other than bloody diarrhea. No toxic, bacterial, viral, or parasitic cause was established. Rectal inflammation was suggested by the presence of fecal leukocytes and was confirmed by sigmoidoscopic observation of focal ulcerations, edema, and increased friability. Rectal biopsies demonstrated a wide spectrum of acute and chronic inflammatory changes. All infants responded clinically to initiation of feeding with either a hydrolyzed casein or a soy protein-based formula. Breast-feeding was subsequently resumed in five of the six infants; all experienced immediate recurrence of symptoms. Elimination of cow milk protein from the maternal diet led to tolerance of breast-feeding in two infants but there was no change in the other three. We believe that dietary protein-induced enterocolitis, previously reported in formula-fed infants, occurs occasionally in the exclusively breast-fed infant as well.
A M Lake; P F Whitington; S R Hamilton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  101     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1982 Dec 
Date Detail:
Created Date:  1983-01-19     Completed Date:  1983-01-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  906-10     Citation Subset:  AIM; IM    
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MeSH Terms
Breast Feeding*
Colitis / etiology*,  pathology
Dietary Proteins / adverse effects*
Infant, Newborn
Infant, Newborn, Diseases / etiology*
Milk, Human
Rectum / pathology
Reg. No./Substance:
0/Dietary Proteins

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