Document Detail

Dietary predictors of perfluorinated chemicals: a study from the Danish National Birth Cohort.
MedLine Citation:
PMID:  19192827     Owner:  NLM     Status:  MEDLINE    
This study investigated the association between dietary variables and plasma levels of perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) among 1076 pregnant women. Diet was assessed at midpregnancy by a food-frequency questionnaire. Mean first trimester plasma PFOS and PFOA levels were 35.1 and 5.6 ng/mL respectively. PFOS levels were positively associated (p < 0.05) with intake of red meat, animal fats, and snacks (e.g., popcorn, potato chips), whereas intake of vegetables and poultry was inversely associated. The adjusted mean differences between the 75th and 25th intake percentiles were 4.3 ng/mL [95% CI: 2.1, 6.5] for red meat 3.4 ng/mL [95% CI: 1.2, 5.6] for animal fats, and 2.0 ng/mL [95% CI: 0.3, 3.6] for snacks. Similar but weaker associations were observed for PFOA. Furthermore, a comparison between women reporting low (< or =25th percentile) red meat and high (> or =75th percentile) vegetable intake and women reporting low vegetable and high red meat intake resulted in differences in plasma PFOS and PFOA concentrations equal to 31% and 18% of mean levels, respectively. Studies quantifying levels of perfluorinated compounds in food have suggested that diet could be an important route of human exposure. The observed associations in our study between dietary variables and maternal exposure further support that conclusion.
Thorhallur I Halldorsson; Chunyuan Fei; Jørn Olsen; Loren Lipworth; Joseph K McLaughlin; Sjurdur F Olsen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Environmental science & technology     Volume:  42     ISSN:  0013-936X     ISO Abbreviation:  Environ. Sci. Technol.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-02-05     Completed Date:  2009-03-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0213155     Medline TA:  Environ Sci Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8971-7     Citation Subset:  IM    
Maternal Nutrition Group, Department of Epidemiology Research, Statens Serum Institut, Arillerivej 5, building 305, 2300 Copenhagen, Denmark.
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MeSH Terms
Alkanesulfonic Acids / blood*
Cohort Studies
Feeding Behavior
Fluorocarbons / blood*
Octanoic Acids / blood*
Pregnancy Trimester, First / blood
Reg. No./Substance:
0/Alkanesulfonic Acids; 0/Fluorocarbons; 0/Octanoic Acids; 1763-23-1/perfluorooctane sulfonic acid; 335-67-1/perfluorooctanoic acid

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