Document Detail

Dietary potential renal acid load and renal net acid excretion in healthy, free-living children and adolescents.
MedLine Citation:
PMID:  12716680     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: There is increasing evidence that acid-base status has a significant effect on high-intensity physical performance, urolithiasis, and calcium metabolism. Experimental studies in adults showed that renal net acid excretion (NAE) can be reliably estimated from the composition of diets. OBJECTIVE: We investigated whether a reasonable estimation of NAE is also possible from the dietary records of free-living children and adolescents. DESIGN: Healthy children (aged 8 y; n = 165) and adolescents (aged 16-18 y; n = 73) each collected a 24-h urine sample and completed a weighed diet record on the same day. Urinary NAE was analyzed (NAE(an)) and estimated (NAE(es)). Potential renal acid load (PRAL), the diet-based component of NAE(es), corrects for intestinal absorption of ingested minerals and sulfur-containing protein. A urinary excretion rate of organic acids (OAs) proportional to body surface area was assumed for the complete estimate (NAE(es) = PRAL + OA(es)). RESULTS: Significant (P < 0.001) correlations between NAE(es) and NAE(an) were seen in the children (r = 0.43) and the adolescents (r = 0.51). A simplified estimate based on only 4 components of dietary PRAL (protein, phosphorus, potassium, and magnesium) yielded almost identical associations. Mean simplified NAE(es) (32.6 +/- 13.9 and 58.4 +/- 22.0 mEq/d in the children and the adolescents, respectively) agreed reasonably with NAE(an) (32.4 +/- 15.5 and 52.8 +/- 24.3 mEq/d, respectively). CONCLUSIONS: Predicting NAE from dietary intakes, food tables, and anthropometric data is also applicable during growth and yields appropriate estimates even when self-selected diets are consumed. The PRAL estimate based on only 4 nutrients may allow relatively simple assessment of the acidity of foods and diets.
Thomas Remer; Triantafillia Dimitriou; Friedrich Manz
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  77     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-04-28     Completed Date:  2003-05-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1255-60     Citation Subset:  AIM; IM    
Department of Nutrition and Health, the Research Institute of Child Nutrition, Dortmund, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acid-Base Equilibrium
Acids / urine*
Biological Availability
Biological Markers / urine
Calcium, Dietary / administration & dosage,  pharmacokinetics
Diet Records*
Dietary Proteins / administration & dosage,  pharmacokinetics
Electrolytes / urine
Growth / physiology
Intestinal Absorption
Kidney / metabolism*
Magnesium / administration & dosage,  pharmacokinetics
Phosphorus, Dietary / administration & dosage,  pharmacokinetics
Physical Exertion / physiology
Potassium, Dietary / administration & dosage,  pharmacokinetics
Predictive Value of Tests
Reg. No./Substance:
0/Acids; 0/Biological Markers; 0/Calcium, Dietary; 0/Dietary Proteins; 0/Electrolytes; 0/Phosphorus, Dietary; 0/Potassium, Dietary; 7439-95-4/Magnesium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Fetal femur length is influenced by maternal dairy intake in pregnant African American adolescents.
Next Document:  Glycomacropeptide and alpha-lactalbumin supplementation of infant formula affects growth and nutriti...