| Dietary poorly absorbed, short-chain carbohydrates increase delivery of water and fermentable substrates to the proximal colon. | |
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MedLine Citation:
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PMID: 20102355 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Functional gut symptoms are induced by inclusion and reduced by dietary restriction of poorly absorbed short-chain carbohydrates (FODMAPs), but the mechanisms of action remain untested. AIMS: To determine the effect of dietary FODMAPs on the content of water and fermentable substrates of ileal effluent. METHODS: Twelve ileostomates without evidence of small intestinal disease undertook two 4-day dietary periods, comprising diets differing only in FODMAP content in a randomized, cross-over, single-blinded intervention study. Daytime (14 h) ileal effluent was collected on day four of each diet. Patients rated effluent volume and consistency on a 10-cm visual analogue scale. The FODMAP content of the diet and effluent was measured. RESULTS: Ingested FODMAPs of 32% (range 6-73%) was recovered in the high FODMAP diet effluent. Effluent collection weight increased by a mean of 22% (95% CI, 5-39), water content by 20% (2-38%) and dry weight by 24% (4-43%) with the high compared to low FODMAP diet arm. Output increased by 95 (28-161) mL. Volunteers perceived effluent consistency was thicker (95% CI, 0.6-1.9) with the low FODMAP diet than with the high FODMAP diet (3.5-6.1; P = 0.006). CONCLUSIONS: These data support the hypothetical mechanism; FODMAPs increase delivery of water and fermentable substrates to the proximal colon. |
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Authors:
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J S Barrett; R B Gearry; J G Muir; P M Irving; R Rose; O Rosella; M L Haines; S J Shepherd; P R Gibson |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2010-01-22 |
Journal Detail:
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Title: Alimentary pharmacology & therapeutics Volume: 31 ISSN: 1365-2036 ISO Abbreviation: Aliment. Pharmacol. Ther. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-26 Completed Date: 2010-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8707234 Medline TA: Aliment Pharmacol Ther Country: England |
Other Details:
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Languages: eng Pagination: 874-82 Citation Subset: IM |
Affiliation:
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Monash University Department of Medicine, Box Hill Hospital, Box Hill, Vic., Australia. Jacqueline.barrett@med.monash.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Colon / metabolism* Cross-Over Studies Dietary Carbohydrates / pharmacokinetics* Dietary Proteins Feces / chemistry Humans Intestinal Absorption / physiology Intestine, Small / metabolism Male Middle Aged Single-Blind Method Water / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Dietary Carbohydrates; 0/Dietary Proteins; 7732-18-5/Water |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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