Document Detail

Dietary polyunsaturated fatty acids modulate resistance to Mycobacterium tuberculosis in guinea pigs.
MedLine Citation:
PMID:  18936208     Owner:  NLM     Status:  MEDLINE    
It is well established that the nutritional status of the host affects resistance to disease. The impact of dietary lipids on experimental pulmonary infection with mycobacteria has not been investigated. Therefore, the purpose of this study was to determine the role of dietary (n-3) and (n-6) fatty acids on immunity and resistance to aerosol infection with virulent Mycobacterium tuberculosis in guinea pigs. Weanling guinea pigs were fed purified, isocaloric diets differing only in lipid source, and the effects of diet on specific immune cell functions were evaluated after 3 or 6 wk. Dietary (n-3) fatty acid consumption reduced in vivo skin test and in vitro lympho-proliferative responses (P < 0.05) relative to (n-6) fatty acid consumption. The effect of diet on resistance to mycobacterial infection was assessed by enumerating viable mycobacteria in the lungs and spleens of guinea pigs infected with virulent M. tuberculosis by the aerosol route. (n-3) Fatty acid-fed guinea pigs had more bacteria in the lungs compared with (n-6) fatty acid-fed guinea pigs at 3 (P < 0.05) and 6 wk postinfection (P < 0.01). These data document the immunomodulatory effects of (n-3) fatty acid consumption in the context of tuberculosis resistance. The loss of antigen-specific T-cell functions in addition to impaired resistance to mycobacterial disease suggests a susceptible phenotype in (n-3) fatty acid-fed guinea pigs.
Christine T McFarland; Yang-Yi Fan; Robert S Chapkin; Bradley R Weeks; David N McMurray
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of nutrition     Volume:  138     ISSN:  1541-6100     ISO Abbreviation:  J. Nutr.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-21     Completed Date:  2008-12-01     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2123-8     Citation Subset:  IM    
Department of Microbial and Molecular Pathogenesis, Texas A&M Health Science Center, College Station, TX 77843, USA.
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MeSH Terms
Antigens, Bacterial / metabolism
Cell Proliferation / drug effects
Cytokines / metabolism
Dietary Fats, Unsaturated / pharmacology*
Fatty Acids, Omega-3 / pharmacology*
Fatty Acids, Omega-6 / pharmacology*
Gene Expression Regulation
Guinea Pigs
Lymphocytes / cytology,  drug effects,  physiology
Mitogens / metabolism
Mycobacterium tuberculosis*
RNA, Messenger / genetics,  metabolism
Tuberculosis / prevention & control*
Grant Support
P30ESO9106//PHS HHS; R01 DK 071707/DK/NIDDK NIH HHS; R01-A1-15495//PHS HHS
Reg. No./Substance:
0/Antigens, Bacterial; 0/Cytokines; 0/Dietary Fats, Unsaturated; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Mitogens; 0/RNA, Messenger

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