| Dietary polyamines are essential luminal growth factors for small intestinal and colonic mucosal growth and development. | |
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MedLine Citation:
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PMID: 9862820 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Polyamines are essential for cell growth. Dietary and probably gut bacterial derived polyamines contribute significantly to the polyamine body pool. AIMS: To evaluate the influence of dietary, luminal polyamines on growth and development of different gastrointestinal organs in normally growing rats. METHODS: Male suckling Wistar rats were randomly allocated to four treatment groups: polyamine deficient diet (PDD); PDD plus antibiotics (neomycin 2 g/kg and metronidazole 34 mg/kg); PDD plus polyamine supplementation at normal concentrations; or normal standard laboratory chow. After a six month feeding period 7-10 animals/group were sacrificed. RESULTS: No differences in body weight gain, food consumption, or general behaviour could be observed between the four groups of animals. Feeding of PDD alone or PDD plus antibiotics resulted in a highly significant decrease in organ weight, protein content, and DNA content in small intestinal and colonic mucosa whereas no alterations were found in the liver. CONCLUSIONS: Long term feeding of polyamine deficient diets resulted in a significant hypoplasia of small intestinal and colonic mucosa. Dietary, luminal polyamines are important local factors for growth and the development of small intestinal and colonic mucosa. |
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Authors:
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C Löser; A Eisel; D Harms; U R Fölsch |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Gut Volume: 44 ISSN: 0017-5749 ISO Abbreviation: Gut Publication Date: 1999 Jan |
Date Detail:
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Created Date: 1999-04-21 Completed Date: 1999-04-21 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2985108R Medline TA: Gut Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 12-6 Citation Subset: AIM; IM |
Affiliation:
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I Medical Department, Christian-Albrechts University, Schittenhelmstrasse 12, D-24105 Kiel, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animal Nutritional Physiological Phenomena* Animals Anti-Bacterial Agents / pharmacology Body Weight / drug effects Colon / drug effects*, growth & development, pathology DNA / analysis Diet* Intestinal Mucosa / drug effects, growth & development Intestine, Small / drug effects*, growth & development, pathology Male Polyamines / metabolism, pharmacology* Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Polyamines; 9007-49-2/DNA |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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