Document Detail

Dietary phytoestrogens and vascular function in postmenopausal women: a cross-sectional study.
MedLine Citation:
PMID:  15201555     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the effects of low levels of intake of phytoestrogens in Western habitual diet on vascular function. DESIGN: A cross-sectional study. SETTING: A population-based study. PARTICIPANTS: A total of 301 postmenopausal women aged 60-75 years living in The Netherlands. DETERMINANT: Dietary phytoestrogen intake as assessed using a food frequency questionnaire covering the year prior to enrollment. MAIN OUTCOME MEASURES: Blood pressure, hypertension, endothelial function and ankle brachial index. RESULTS: The median isoflavone intake was 0.2 mg in the lowest tertile and 11.4 mg in the highest tertile. Median lignan intake was 0.8 and 2.2 mg, respectively. No associations were found for higher intake of isoflavones, systolic and diastolic blood pressures, ankle-arm blood pressure index, endothelial function or hypertension. For lignans no association was found for ankle-arm blood pressure index or endothelial function, but we did observe lower systolic and diastolic blood pressures and a lower prevalence of hypertension (systolic blood pressure difference T3-T1, -11.2 mmHg, 95% confidence interval = -17.8 to -4.5, P for trend = 0.001; diastolic blood pressure difference T3-T1, -3.6 mmHg, 95% confidence interval = -7.8 to 0.6, P for trend = 0,08; and prevalence of hypertension, odds ratio T3 versus T1 = 0.41, 95% confidence interval = 0.22-0.76, P for trend over tertiles = 0.004). CONCLUSION: The results of this study suggest a protective effect of dietary lignan intake on blood pressure and hypertension, even at low levels.
Sanne Kreijkamp-Kaspers; Linda Kok; Michiel L Bots; Diederick E Grobbee; Yvonne T van der Schouw
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of hypertension     Volume:  22     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-06-17     Completed Date:  2005-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  1381-8     Citation Subset:  IM    
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands.
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MeSH Terms
Blood Pressure / drug effects*
Brachial Artery / physiology
Cross-Sectional Studies
Diet Surveys
Hypertension / diet therapy*,  epidemiology,  prevention & control*
Lignans / administration & dosage
Middle Aged
Phytoestrogens / administration & dosage*
Reg. No./Substance:
0/Lignans; 0/Phytoestrogens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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