Document Detail

Dietary, physiological, genetic and pathological influences on postprandial lipid metabolism.
MedLine Citation:
PMID:  17705891     Owner:  NLM     Status:  MEDLINE    
Most of diurnal time is spent in a postprandial state due to successive meal intakes during the day. As long as the meals contain enough fat, a transient increase in triacylglycerolaemia and a change in lipoprotein pattern occurs. The extent and kinetics of such postprandial changes are highly variable and are modulated by numerous factors. This review focuses on factors affecting postprandial lipoprotein metabolism and genes, their variability and their relationship with intermediate phenotypes and risk of CHD. Postprandial lipoprotein metabolism is modulated by background dietary pattern as well as meal composition (fat amount and type, carbohydrate, protein, fibre, alcohol) and several lifestyle conditions (physical activity, tobacco use), physiological factors (age, gender, menopausal status) and pathological conditions (obesity, insulin resistance, diabetes mellitus). The roles of many genes have been explored in order to establish the possible implications of their variability in lipid metabolism and CHD risk. The postprandial lipid response has been shown to be modified by polymorphisms within the genes for apo A-I, A-IV, A-V, E, B, C-I and C-III, lipoprotein lipase, hepatic lipase, fatty acid binding and transport proteins, microsomal triglyceride transfer protein and scavenger receptor class B type I. Overall, the variability in postprandial response is important and complex, and the interactions between nutrients or dietary or meal compositions and gene variants need further investigation. The extent of present knowledge and needs for future studies are discussed in light of ongoing developments in nutrigenetics.
José Lopez-Miranda; Christine Williams; Denis Lairon
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The British journal of nutrition     Volume:  98     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-20     Completed Date:  2007-10-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  458-73     Citation Subset:  IM    
Lipids and Atherosclerosis Research Unit, Department of Medicine, Hospital Universitario Reina Sofía, University of Cordoba, Córdoba, Spain.
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MeSH Terms
Apolipoproteins / genetics,  metabolism
Atherosclerosis / genetics,  metabolism
Coronary Disease / genetics,  metabolism
Dietary Carbohydrates / administration & dosage,  metabolism
Dietary Fats / administration & dosage,  metabolism
Dietary Fiber / administration & dosage,  metabolism
Dietary Proteins / metabolism
Hyperlipidemias / genetics,  metabolism
Hypertriglyceridemia / genetics,  metabolism
Life Style
Lipid Metabolism / genetics,  physiology*
Obesity / genetics,  metabolism
Polymorphism, Genetic
Postprandial Period / genetics,  physiology*
Reg. No./Substance:
0/Apolipoproteins; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Dietary Proteins

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