| Dietary phosphate restriction in dialysis patients: A new approach for the treatment of hyperphosphataemia. | |
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MedLine Citation:
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PMID: 20609572 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND AND AIM: Elevated serum phosphate and calcium-phosphate levels play an important role in the pathogenesis of vascular calcifications in uraemic patients and appear to be associated with increased cardiovascular mortality. We aimed to evaluate the effects of a partial replacement of food protein with a low-phosphorus and low-potassium whey protein concentrate on phosphate levels of dialysis patients with hyperphosphataemia. METHODS AND RESULTS: Twenty-seven patients undergoing chronic haemodialysis were studied for a 3-month period. In the intervention group (n = 15), food protein were replaced by 30 or 40 g of low-phosphorus and low-potassium protein concentrate aimed at limiting the phosphate intake. In the control group (n = 12) no changes were made to their usual diet. Anthropometric measurements, biochemical markers and dietary interviews were registered at baseline and during the follow-up period. From baseline to the end of the study, in the intervention group, serum phosphate and circulating intact parathyroid hormone levels lessened significantly (8.3 ± 1.2 mg/dL vs 5.7 ± 1.4 mg/dL and 488 ± 205 pg/ml vs 177 ± 100 pg/ml respectively; p < 0.05) with decreasing of phosphate and potassium intake. No significant differences were found in the control group. No significant changes were observed in serum albumin, calcium, potassium, Kt/V, body weight and body composition in both the intervention and control groups. CONCLUSION: Dietary intake of phosphate mainly comes from protein sources, so dietary phosphorus restriction may lead to a protein/energy malnutrition in a dialysis patient. A phosphorus-controlled diet plan including a nutritional substitute resulted in serum phosphate and intact parathyroid hormone decrease without nutritional status modifications in dialysis patients. |
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Authors:
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B Guida; A Piccoli; R Trio; R Laccetti; A Nastasi; A Paglione; A Memoli; B Memoli |
Publication Detail:
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Type: Journal Article Date: 2010-07-06 |
Journal Detail:
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Title: Nutrition, metabolism, and cardiovascular diseases : NMCD Volume: 21 ISSN: 1590-3729 ISO Abbreviation: Nutr Metab Cardiovasc Dis Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-10-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9111474 Medline TA: Nutr Metab Cardiovasc Dis Country: Netherlands |
Other Details:
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Languages: eng Pagination: 879-84 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Neuroscience, Physiology Nutrition Unit, University Federico II, Naples, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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