| Dietary pectin stimulates protein metabolism in the digestive tract. | |
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MedLine Citation:
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PMID: 17084594 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of this study was to determine if protein metabolism was altered in small and large intestines by feeding pectin, a soluble fiber known to stimulate cecal production of short-chain fatty acids (SCFAs) and to have a trophic effect in these tissues. METHODS: Twenty-four weanling male Sprague-Dawley rats were fed ad libitum for 14 d with a balanced control diet or an isoproteic, isocaloric pectin (citrus) diet (80 g/kg). SCFA production, intestinal histomorphometry, and protein synthesis were determined in the proximal and distal parts of the small intestine, the cecum, and the colon. Protein synthesis rates were determined by measuring the (13)C valine incorporation rate in tissue proteins. RESULTS: Pectin feeding slightly decreased food intake and growth rate. It increased the acetate, propionate, and butyrate pools in the cecum. Pectin feeding resulted in heavier intestinal tissues corresponding to higher villus height in the small intestine and crypt depth in the small and large intestines compared with feeding of the control diet. Compared with the control group, the rats fed the pectin diet had significantly higher protein synthesis rates in all the parts of their intestines. CONCLUSION: Supplementation of pectin, as a soluble fiber, in the diets, stimulated SCFA production, had a trophic effect on the different parts of the intestines, and greatly stimulated protein synthesis in those tissues. |
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Authors:
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Tatjana Pirman; Marie Claude Ribeyre; Laurent Mosoni; Didier Rémond; Milka Vrecl; Janez Salobir; Philippe Patureau Mirand |
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Publication Detail:
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Type: Journal Article Date: 2006-11-02 |
Journal Detail:
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Title: Nutrition (Burbank, Los Angeles County, Calif.) Volume: 23 ISSN: 0899-9007 ISO Abbreviation: Nutrition Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2006-12-25 Completed Date: 2007-03-13 Revised Date: 2007-07-09 |
Medline Journal Info:
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Nlm Unique ID: 8802712 Medline TA: Nutrition Country: United States |
Other Details:
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Languages: eng Pagination: 69-75 Citation Subset: IM |
Affiliation:
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University of Ljubljana, Biotechnical Faculty, Zootechnical Department, Domzale, Slovenia. tatjana.pirman@bfro.uni-lj.si |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbon Isotopes Dietary Fiber / administration & dosage*, pharmacology Fatty Acids, Volatile / biosynthesis Intestines / drug effects*, growth & development, metabolism, pathology Male Organ Size Pectins / administration & dosage*, pharmacology Protein Biosynthesis / drug effects* Proteins / drug effects, metabolism* Random Allocation Rats Rats, Sprague-Dawley Solubility Valine / metabolism*, pharmacokinetics |
| Chemical | |
Reg. No./Substance:
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0/Carbon Isotopes; 0/Fatty Acids, Volatile; 0/Pectins; 0/Proteins; 7004-03-7/Valine; 9000-69-5/pectin |
| Comments/Corrections | |
Comment In:
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Nutrition. 2007 May;23(5):434-5
[PMID:
17483011
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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