| Dietary patterns, food groups, and telomere length in the Multi-Ethnic Study of Atherosclerosis (MESA). | |
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MedLine Citation:
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PMID: 18996878 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Telomere length reflects biological aging and may be influenced by environmental factors, including those that affect inflammatory processes. OBJECTIVE: With data from 840 white, black, and Hispanic adults from the Multi-Ethnic Study of Atherosclerosis, we studied cross-sectional associations between telomere length and dietary patterns and foods and beverages that were associated with markers of inflammation. DESIGN: Leukocyte telomere length was measured by quantitative polymerase chain reaction. Length was calculated as the amount of telomeric DNA (T) divided by the amount of a single-copy control DNA (S) (T/S ratio). Intake of whole grains, fruit and vegetables, low-fat dairy, nuts or seeds, nonfried fish, coffee, refined grains, fried foods, red meat, processed meat, and sugar-sweetened soda were computed with responses to a 120-item food-frequency questionnaire completed at baseline. Scores on 2 previously defined empirical dietary patterns were also computed for each participant. RESULTS: After adjustment for age, other demographics, lifestyle factors, and intakes of other foods or beverages, only processed meat intake was associated with telomere length. For every 1 serving/d greater intake of processed meat, the T/S ratio was 0.07 smaller (beta +/- SE: -0.07 +/- 0.03, P = 0.006). Categorical analysis showed that participants consuming >or=1 serving of processed meat each week had 0.017 smaller T/S ratios than did nonconsumers. Other foods or beverages and the 2 dietary patterns were not associated with telomere length. CONCLUSIONS: Processed meat intake showed an expected inverse association with telomere length, but other diet features did not show their expected associations. |
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Authors:
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Jennifer A Nettleton; Ana Diez-Roux; Nancy S Jenny; Annette L Fitzpatrick; David R Jacobs |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 88 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-11-10 Completed Date: 2008-12-01 Revised Date: 2011-07-25 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 1405-12 Citation Subset: AIM; IM |
Affiliation:
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Division of Epidemiology and Disease Control, University of Texas Health Sciences Center, Houston, TX 77005, USA. jennifer.a.nettleton@uth.tmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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African Continental Ancestry Group Aged Aged, 80 and over Aging / physiology* Atherosclerosis / epidemiology*, ethnology* Biological Markers / blood Continental Population Groups Cross-Sectional Studies Diet* Ethnic Groups European Continental Ancestry Group Female Food Habits Humans Inflammation / metabolism Male Meat Products / adverse effects* Middle Aged Risk Factors Telomere / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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M01-RR00645/RR/NCRR NIH HHS; N01 HC095163/HC/NHLBI NIH HHS; N01-HC-95159/HC/NHLBI NIH HHS; N01-HC-95160/HC/NHLBI NIH HHS; N01-HC-95161/HC/NHLBI NIH HHS; N01-HC-95162/HC/NHLBI NIH HHS; N01-HC-95163/HC/NHLBI NIH HHS; N01-HC-95164/HC/NHLBI NIH HHS; N01-HC-95165/HC/NHLBI NIH HHS; N01-HC-95166/HC/NHLBI NIH HHS; N01-HC-95169/HC/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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