Document Detail

Dietary origin of mycotoxins with estrogenic potential and possible health implications to female dogs.
MedLine Citation:
PMID:  15633795     Owner:  NLM     Status:  MEDLINE    
In Poland, occurrence of toxigenic fungi in cereals, foods, feeds and their components as well as mycotoxins accumulation in such material has been studied by numerous teams including our research group for over thirty years since 1969. Mostly cereal kernels and feeds have been examined for presence of toxigenic fungi, their toxigenic potential and natural contamination with mycotoxins. Ochratoxin A, deoxynivalenol, nivalenol and moniliformin were found to be significant contaminants of agricultural products in high percentage of cereal grain samples. The profile of toxic metabolites was similar but the concentration levels of the toxins were lower when compared to already published data of the same climate zone. Zearalenone (ZEA), a nonsteroidal mycotoxin with estrogen-like activity, is synthesized by molds (Fusarium) commonly contaminating poorly stored agricultural products and foodstuffs. Since in the course of examinations and during surgical procedures performed in dogs, ovarian cysts were detected and because frequently this is the first stage of the endometrica pyometra complex (EPC) found in approximately 30% of the females we assume that both factors, mycotoxins (ZEA) and pathological aberrations are possibly related in these animals. Similar activity of the toxin (possibly present in pelleted dog feed) and effects including infertility of female dogs is speculated with indication and suggestion on necessity of additional studies on the problem.
P K Golinski; T Nowak
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Polish journal of veterinary sciences     Volume:  7     ISSN:  1505-1773     ISO Abbreviation:  Pol J Vet Sci     Publication Date:  2004  
Date Detail:
Created Date:  2005-01-06     Completed Date:  2005-02-08     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  101125473     Medline TA:  Pol J Vet Sci     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  337-41     Citation Subset:  IM    
Department of Chemistry, August Cieszkowski Agricultural University, ul Wojska Polskiego 75, 60-25 Poznan, Poland.
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MeSH Terms
Animal Feed*
Estrogens / toxicity*
Food Contamination*
Mycotoxins / toxicity*
Reproduction / drug effects*
Reg. No./Substance:
0/Estrogens; 0/Mycotoxins

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