Document Detail


Dietary oral exposure to l,3,5-trinitro-1,3,5-triazine in the northern bobwhite (Colinus virginianus).
MedLine Citation:
PMID:  12558171     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The potential risk to wildlife from exposure to explosives, including 1,3,5-trinitro-1,3,5-triazine (RDX), has been an issue at numerous U.S. military installations where these substances are found in soil and water. Presently, no data describing the effects of RDX exposure in avian species exist. Therefore, an acute lethal dose (ALD) and 14- and 90-d subchronic dietary exposures to RDX were evaluated in a species potentially present at many contaminated sites, i.e., the northern bobwhite (Colinus virginianus). The ALDs for females and males were 187 and 280 mg/kg, respectively. Data from the 14-d dietary trial suggested that RDX exposure inhibited food consumption, weight gain, and egg production. Dietary RDX exposure for 90-d produced a dose-dependant decreasing trend in total feed consumption, total egg production, and hen-housed production parameters. These collective data suggest that quail may respond differently to oral RDX exposure compared with mammals.
Authors:
Obert M Gogal; Mark S Johnson; Calvert T Larsen; Mary R Prater; Robert B Duncan; Daniel L Ward; Robyn B Lee; Christopher J Salice; Bernard Jortner; Steven D Holladay
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Environmental toxicology and chemistry / SETAC     Volume:  22     ISSN:  0730-7268     ISO Abbreviation:  Environ. Toxicol. Chem.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-01-31     Completed Date:  2003-04-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8308958     Medline TA:  Environ Toxicol Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  381-7     Citation Subset:  IM    
Affiliation:
Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, Virginia 24061, USA.
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MeSH Terms
Descriptor/Qualifier:
Acute Toxicity Tests
Administration, Oral
Animal Feed
Animals
Apoptosis / drug effects
Blood Cell Count
Blood Proteins / analysis
Body Weight / drug effects
Colinus / blood,  growth & development*
Environmental Pollutants / toxicity*
Female
Leukocytes / drug effects
Liver / drug effects,  pathology
Male
Organ Size / drug effects
Spleen / drug effects,  pathology
Toxicity Tests*
Toxicity Tests, Chronic
Triazines / toxicity*
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/Environmental Pollutants; 0/Triazines; 121-82-4/cyclonite

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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