Document Detail

Dietary omega-3 fatty acids and fish consumption and risk of type 2 diabetes.
MedLine Citation:
PMID:  20980491     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although dietary omega-3 (n-3) fatty acids may confer some cardiovascular benefits, it is unclear whether these nutrients may also unfavorably affect risk of type 2 diabetes (T2D).
OBJECTIVE: We evaluated whether dietary omega-3 fatty acids and fish consumption were associated with increased risk of T2D.
DESIGN: This was a prospective study of 36,328 women (mean age: 54.6 y) who participated in the Women's Health Study and who were followed from 1992 to 2008. Incident T2D was self-reported and validated primarily through the collection of supplementary information from participants. Information on omega-3 and fish intakes was obtained by using a validated food-frequency questionnaire. We used Cox proportional hazard models to estimate adjusted relative risks.
RESULTS: During an average follow-up of 12.4 y, 2370 women developed T2D. Marine but not plant-based omega-3 fatty acids were positively associated with incident T2D. From the lowest to highest quintiles of marine omega-3 intake, the multivariable-adjusted hazard ratios (95% CIs) for T2D were 1.0 (referent), 1.17 (1.03, 1.33), 1.20 (1.05, 1.38), 1.46 (1.28, 1.66), and 1.44 (1.25, 1.65), respectively (P for trend < 0.0001). A similar association was observed with fish intake, but additional adjustment for docosahexaenoic acid led to the elimination of the association. The relation between marine omega-3 fatty acids and T2D was observed in hypertensive and nonhypertensive subjects and in women who reported infrequent fish consumption.
CONCLUSION: Our data suggest an increased risk of T2D with the intake of long-chain omega-3 fatty acids, especially with higher intakes (≥ 0.20 g omega-3/d or ≥ 2 servings of fish/d). The Women's Health Study was registered at as NCT00000479.
Luc Djoussé; J Michael Gaziano; Julie E Buring; I-Min Lee
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2010-10-27
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  93     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-21     Completed Date:  2011-01-27     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  143-50     Citation Subset:  AIM; IM    
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MeSH Terms
Diabetes Mellitus, Type 2 / etiology*
Double-Blind Method
Fatty Acids, Omega-3 / administration & dosage*
Middle Aged
Prospective Studies
Women's Health
Grant Support
Reg. No./Substance:
0/Fatty Acids, Omega-3
Comment In:
Am J Clin Nutr. 2011 Aug;94(2):617-8; author reply 618-9   [PMID:  21775573 ]

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