| Dietary omega-3 fatty acids and fish consumption and risk of type 2 diabetes. | |
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MedLine Citation:
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PMID: 20980491 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Although dietary omega-3 (n-3) fatty acids may confer some cardiovascular benefits, it is unclear whether these nutrients may also unfavorably affect risk of type 2 diabetes (T2D). OBJECTIVE: We evaluated whether dietary omega-3 fatty acids and fish consumption were associated with increased risk of T2D. DESIGN: This was a prospective study of 36,328 women (mean age: 54.6 y) who participated in the Women's Health Study and who were followed from 1992 to 2008. Incident T2D was self-reported and validated primarily through the collection of supplementary information from participants. Information on omega-3 and fish intakes was obtained by using a validated food-frequency questionnaire. We used Cox proportional hazard models to estimate adjusted relative risks. RESULTS: During an average follow-up of 12.4 y, 2370 women developed T2D. Marine but not plant-based omega-3 fatty acids were positively associated with incident T2D. From the lowest to highest quintiles of marine omega-3 intake, the multivariable-adjusted hazard ratios (95% CIs) for T2D were 1.0 (referent), 1.17 (1.03, 1.33), 1.20 (1.05, 1.38), 1.46 (1.28, 1.66), and 1.44 (1.25, 1.65), respectively (P for trend < 0.0001). A similar association was observed with fish intake, but additional adjustment for docosahexaenoic acid led to the elimination of the association. The relation between marine omega-3 fatty acids and T2D was observed in hypertensive and nonhypertensive subjects and in women who reported infrequent fish consumption. CONCLUSION: Our data suggest an increased risk of T2D with the intake of long-chain omega-3 fatty acids, especially with higher intakes (≥ 0.20 g omega-3/d or ≥ 2 servings of fish/d). The Women's Health Study was registered at clinicaltrials.gov as NCT00000479. |
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Authors:
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Luc Djoussé; J Michael Gaziano; Julie E Buring; I-Min Lee |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural Date: 2010-10-27 |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 93 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-21 Completed Date: 2011-01-27 Revised Date: 2012-01-02 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 143-50 Citation Subset: AIM; IM |
Affiliation:
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Division of Aging and Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. ldjousse@rics.bwh.harvard.edu |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00000479 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diabetes Mellitus, Type 2 / etiology* Diet* Double-Blind Method Fatty Acids, Omega-3 / administration & dosage* Female Fishes* Humans Middle Aged Prospective Studies Women's Health |
| Grant Support | |
ID/Acronym/Agency:
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CA-047988/CA/NCI NIH HHS; HL-043851/HL/NHLBI NIH HHS; HL-080467/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Omega-3 |
| Comments/Corrections | |
Comment In:
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Am J Clin Nutr. 2011 Aug;94(2):617-8; author reply 618-9
[PMID:
21775573
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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