Document Detail


Dietary omega-3 fatty acids and ganglion cell function.
MedLine Citation:
PMID:  18469188     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Diet-induced deficiencies in Omega-3 (omega-3) fatty acids are well known to alter photoreceptor function. In this study, the broader functional changes in a diversity of retinal neurons were considered. METHODS: Sprague-Dawley dams were fed either omega-3-sufficient (omega-3(+), n = 21) or -deficient (omega-3(-), n = 19) diets 5 weeks before conception, with the pups continued on the mothers' diet. After 20 weeks of age, electroretinograms (ERGs) were recorded by using protocols that isolate separate cellular generators, including; photoreceptors (PIII), ON-bipolar cells (PII), and ganglion/amacrine cells (STR). At the brightest energies, rod and cone responses were isolated with a paired-flash paradigm. Retinal tissue (omega-3(+), n = 5; omega-3(-), n = 5) was harvested at 23 weeks of age for fatty acid assays with thin layer and gas liquid chromatography. RESULTS: Omega-3 deficiency caused a 48.6% decrease in total retinal docosahexaenoic acid (DHA). This change induced significant amplitude decreases only in the rod PII (-8.2%) and positive (p)STR components (-27.4%), with widespread delays in all signals (PIII 5.7%, PII 13.6%, pSTR 7.6%, and negative [n]STR 8.3%). Omega-3 deficiency exerted its greatest effects on signals originating in the inner retina (pSTR). CONCLUSIONS: Increasing dietary omega-3 has beneficial effects across the retina, with the greatest improvement occurring in ganglion cell function.
Authors:
Christine T O Nguyen; Algis J Vingrys; Bang V Bui
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-05-09
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  49     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-28     Completed Date:  2008-08-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3586-94     Citation Subset:  IM    
Affiliation:
Department of Optometry and Vision Sciences, University of Melbourne, Parkville, Victoria, Australia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromatography, Gas
Chromatography, Thin Layer
Dietary Fats, Unsaturated / administration & dosage*
Docosahexaenoic Acids / metabolism
Electroretinography
Fatty Acids, Omega-3 / administration & dosage*
Fatty Acids, Unsaturated / analysis
Female
Lipids / deficiency*
Photic Stimulation
Photoreceptor Cells, Vertebrate / physiology*
Pregnancy
Rats
Rats, Sprague-Dawley
Retina / metabolism
Retinal Bipolar Cells / physiology
Retinal Ganglion Cells / physiology*
Chemical
Reg. No./Substance:
0/Dietary Fats, Unsaturated; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Unsaturated; 0/Lipids; 25167-62-8/Docosahexaenoic Acids

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