Document Detail

Dietary olive oil supplemented with fish oil, rich in EPA and DHA (n-3) polyunsaturated fatty acids, attenuates colonic inflammation in rats with DSS-induced colitis.
MedLine Citation:
PMID:  15795419     Owner:  NLM     Status:  MEDLINE    
Previous studies proposed a protective role of the dietary intake of (n-3) PUFA in human inflammatory bowel disease (IBD), but almost no studies have been performed using olive oil. The aims of the present study were to test the beneficial effects of an olive oil-based diet with or without fish oil, rich in (n-3) PUFA, in the dextran sodium sulfate (DSS) model of rat colitis and to elucidate the mechanisms involved in their potential beneficial effects, with special attention to the production of some of the mediators involved in the intestinal inflammatory response, such as leukotriene B(4) (LTB(4)), tumor necrosis factor alpha (TNFalpha) and nitric oxide (NO). Rats were fed the different diets for 2 wk before colitis induction and thereafter until colonic evaluation 15 d later. Colitic rats fed the olive oil-based diet had a lower colonic inflammatory response than those fed the soybean oil diet, and this beneficial effect was increased by the dietary incorporation of (n-3) PUFA. A restoration of colonic glutathione levels and lower colonic NO synthase expression occurred in all colitic rats fed an olive oil diet compared with the control colitic group that consumed the soybean oil diet. However, (n-3) PUFA incorporation into an olive oil diet significantly decreased colonic TNFalpha and LTB(4) levels compared with colitic rats that were not supplemented with fish oil. These results affirm the benefits of an olive oil diet in the management of IBD, which are further enhanced by the addition of (n-3) PUFA.
Desirée Camuesco; Julio Gálvez; Ana Nieto; Mònica Comalada; M Elena Rodríguez-Cabezas; Angel Concha; Jordi Xaus; Antonio Zarzuelo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of nutrition     Volume:  135     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-03-29     Completed Date:  2005-05-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  687-94     Citation Subset:  IM    
Department of Pharmacology, School of Pharmacy, University of Granada, Granada, Spain.
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MeSH Terms
Administration, Oral
Colitis / blood,  chemically induced,  metabolism,  prevention & control*
Colon / metabolism
Dextran Sulfate*
Dietary Fats* / administration & dosage
Dietary Fats, Unsaturated / administration & dosage*
Disease Models, Animal
Fatty Acids / analysis
Fatty Acids, Nonesterified / blood
Inflammation / prevention & control*
Liver / metabolism
Plant Oils / administration & dosage
Rats, Wistar
Reg. No./Substance:
0/Dietary Fats; 0/Dietary Fats, Unsaturated; 0/Fatty Acids; 0/Fatty Acids, Nonesterified; 0/Plant Oils; 8001-25-0/olive oil; 9042-14-2/Dextran Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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