Document Detail

Dietary nucleotides and intestinal blood flow velocity in term infants.
MedLine Citation:
PMID:  15187778     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Two previous studies have shown that the addition of nucleotides to single feedings of formula is associated with increased 90-minute postprandial superior mesenteric artery (SMA) blood flow velocity (BFV). To assess the effect of chronic feeding of nucleotide-supplemented formula, we measured pre- and postprandial SMA BFV in term infants fed formula with or without added nucleotides for 4 weeks. METHODS: At 1 week of age, healthy, term infants were randomized to receive formula with added nucleotides (NT+), or formula without added nucleotides (NT-) from age 1 to 5 weeks. When the infants were 5 weeks of age, SMA BFV was measured by Doppler ultrasound 15 minutes before the assigned feeding (baseline) and 30, 60, and 90 minutes after the start of feeding. A reference group of human milk-fed infants was studied before and after breast feeding. RESULTS: Thirty formula-fed (NT+ = 17; NT- = 13) and 10 human milk-fed infants were studied. Baseline BFV was similar among the three groups. BFV increased in each group from baseline to 30 minutes after initiation of feeding and progressively declined from 30 to 90 minutes in infants fed NT- formula or human milk. In infants fed NT+ formula, BFV decreased between 30 and 60 minutes. However, from 60 to 90 minutes, velocity was unchanged or increased. At 90 minutes, mean and peak systolic velocities were significantly greater in the NT+ group than the NT- group (P < 0.001). CONCLUSIONS: These data agree with those of previous studies showing increased 90-minute postprandial SMA BFV after a feeding with nucleotide-supplemented formula. The clinical significance of these findings is unknown.
Jane D Carver; Roberto Sosa; Monisha Saste; Matthew Kuchan
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  39     ISSN:  0277-2116     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-06-09     Completed Date:  2005-01-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  38-42     Citation Subset:  IM    
University of South Florida College of Medicine, Department of Pediatrics, Tampa, Florida, USA.
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MeSH Terms
Blood Flow Velocity / drug effects
Cross-Over Studies
Infant Food
Infant Formula*
Infant Nutritional Physiological Phenomena*
Infant, Newborn
Intestines / blood supply*
Mesenteric Artery, Superior / drug effects,  physiology*,  ultrasonography
Nucleotides / administration & dosage,  pharmacology*
Postprandial Period
Regional Blood Flow
Time Factors
Ultrasonography, Doppler
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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