Document Detail

Dietary nucleotides do not alter erythrocyte long-chain polyunsaturated fatty acids in formula-fed term infants.
MedLine Citation:
PMID:  16149743     Owner:  NLM     Status:  MEDLINE    
There have been conflicting reports regarding the effectiveness of dietary nucleotides (NT) to regulate tissue desaturases and hence stimulate accumulation of both n-6 and n-3 long-chain polyunsaturated fatty acids (LCPUFA). The aim of this study was to examine the effect of NT-supplemented cow's milk-based formula on erythrocyte phospholipid FA status in a large randomized controlled trial involving a well-nourished infant population born at term. Formula-fed infants were allocated to control formula with an innate level of NT at 10 mg/L (n = 102), or formula fortified with NT at 34 mg/L (n = 98). A parallel group of breastfed infants was included as a reference. Peripheral blood samples were collected by venipuncture at 7 mon of age and erythrocyte phospholipid FA determined by capillary GC. Erythrocyte LCPUFA levels did not differ between the NT-supplemented and control formula groups and were reduced in both groups compared with breastfed infants. We conclude that there is no induction of LCPUFA accumulation in erythrocyte phospholipids of term, formula-fed infants following 7 mon of NT supplementation.
Robert A Gibson; Joanna S Hawkes; Maria Makrides
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lipids     Volume:  40     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-09-09     Completed Date:  2005-12-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  United States    
Other Details:
Languages:  eng     Pagination:  631-4     Citation Subset:  IM    
Child Health Research Institute, Flinders Medical Centre and Flinders University, Bedford Park, South Australia 5042, Australia.
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MeSH Terms
Breast Feeding
Erythrocytes / chemistry,  drug effects,  metabolism*
Fatty Acids, Unsaturated / blood*,  chemistry
Gestational Age
Infant Food
Infant Formula / chemistry,  pharmacology*
Infant, Newborn
Nucleotides / pharmacology*
Phospholipids / blood,  chemistry
Reg. No./Substance:
0/Fatty Acids, Unsaturated; 0/Nucleotides; 0/Phospholipids

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