| Dietary nucleotides accelerate intestinal recovery after food deprivation in old rats. | |
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MedLine Citation:
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PMID: 7782893 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous studies in very young rats have shown that dietary nucleotides improve small intestine repair after injury or malnutrition. To investigate the potential effect of nucleotides in old rats, which have a diminished capability for intestinal repair, 17-mo-old rats were deprived of food for 5 d and then fed a nucleotide-free diet or a nucleotide-supplemented diet for 3 or 6 d. Intestinal jejunal and ileal mucosal weight, protein and DNA were evaluated as intestinal growth markers, and brush-border maltase, sucrase, lactase and aminopeptidase activities were evaluated as intestinal differentiation markers. The adenine nucleotide pool and the adenylate energy charge were also evaluated as indices of nucleotide availability. Food deprivation significantly decreased mucosal growth markers as well as differentiation markers in both jejunum and ileum. The ATP pool was also significantly depressed, but the adenylate energy charge was not significantly altered. To a certain extent, refeeding restored the losses, but in the rats that were fed the nucleotide-free diet, the restoration of the jejunum was significantly slower and the restoration of the ileum differentiation markers was incomplete compared with the rats fed the nucleotide-supplemented diet. The results suggest that dietary nucleotide intake in the elderly may accelerate the normal physiological intestinal response to refeeding after food deprivation. |
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Authors:
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M A Ortega; M C Nunez; A Gil; A Sánchez-Pozo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of nutrition Volume: 125 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 1995 Jun |
Date Detail:
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Created Date: 1995-07-18 Completed Date: 1995-07-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1413-8 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Faculty of Pharmacy, University of Granada, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenine Nucleotides
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analysis Adenosine Triphosphate / analysis Aging / physiology* Animals Body Weight / physiology DNA / analysis Eating / physiology Food Deprivation / physiology* Food, Fortified Hypoxanthines / analysis Ileum / drug effects*, growth & development, physiology Intestinal Mucosa / chemistry, enzymology Jejunum / drug effects*, growth & development, physiology Lactase Male Microvilli / enzymology Nucleotides / pharmacology* Proteins / analysis Random Allocation Rats Rats, Wistar Sucrase / analysis alpha-Glucosidases / analysis beta-Galactosidase / analysis |
| Chemical | |
Reg. No./Substance:
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0/Adenine Nucleotides; 0/Hypoxanthines; 0/Nucleotides; 0/Proteins; 56-65-5/Adenosine Triphosphate; 9007-49-2/DNA; EC 3.2.1.108/Lactase; EC 3.2.1.20/alpha-Glucosidases; EC 3.2.1.23/beta-Galactosidase; EC 3.2.1.48/Sucrase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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