Document Detail

Dietary nitrate and nitrite intake and risk of non-Hodgkin lymphoma.
MedLine Citation:
PMID:  23013327     Owner:  NLM     Status:  Publisher    
Abstract Although established risk factors such as immunodeficiency and viral infections may be responsible for a portion of non-Hodgkin lymphoma (NHL) cases, the vast majority of NHL cases remain unexplained. The role of dietary nitrate and nitrite in NHL risk is of interest since they are precursors of N-nitroso compounds and nitrosoureas have been shown to induce B and T-cell lymphomas in animal studies. However, few studies have evaluated the potential association between consumption of nitrate and nitrite intake and NHL by subtype or chromosomal translocation status, and the results of these studies have been inconsistent. We estimated the dietary intake of nitrate and nitrite using a food frequency questionnaire in a population-based, case-control study of 348 cases and 470 controls conducted in Nebraska in 1999-2002. A non-significant excess risk of NHL was found among women who reported an intake of nitrite in the highest quartile compared to the lowest quartile (OR = 1.6; 95% CI: 0.8-2.9), particularly nitrite from animal sources (OR=1.9; 95% CI: 1.0-3.4). No significant associations were observed for nitrate or nitrite by NHL subtype. Although there were some increases in risk that support the N-nitroso hypothesis, they were not significant and do not confer strong evidence of an association.
Briseis Aschebrook-Kilfoy; Mary H Ward; Bhavana J Dave; Sonali M Smith; Dennis D Weisenburger; Brian C-H Chiu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-27
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  -     ISSN:  1029-2403     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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