Document Detail

Dietary n-3 polyunsaturated fatty acid modulation of immune cell function before or after trauma.
MedLine Citation:
PMID:  7749236     Owner:  NLM     Status:  MEDLINE    
We describe the role of increased eicosanoid production in inducing immunodepression associated with shock and trauma and the potential mechanisms by which prostaglandins produce immunosuppression. The effects of prefeeding with a diet high in n-3 polyunsaturated fatty acids (PUFAs) in preventing trauma-induced immunosuppression, and of such a diet on cellular immunity in patients after trauma are described. The potential mechanisms by which enteral diets containing n-3 PUFAs produce beneficial effects are also discussed. Although there is controversy concerning the immunomodulatory mechanisms of this diet, most of the information available indicates that dietary supplementation with n-3 PUFAs may prevent immunosuppression after trauma. Further studies are needed, however, to determine the precise composition and duration of supplementation with n-3 PUFAs that prevent the deleterious immune responses but do not alter normal immunoresponsiveness.
A Ayala; I H Chaudry
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  11     ISSN:  0899-9007     ISO Abbreviation:  Nutrition     Publication Date:    1995 Jan-Feb
Date Detail:
Created Date:  1995-06-22     Completed Date:  1995-06-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-11     Citation Subset:  IM    
Department of Surgery, Michigan State University, East Lansing 48824, USA.
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MeSH Terms
Dietary Fats / administration & dosage,  pharmacology*
Eicosanoids / biosynthesis,  physiology
Fatty Acids, Omega-3 / administration & dosage,  pharmacology*
Immunologic Deficiency Syndromes / etiology,  prevention & control
Wounds and Injuries / immunology*
Grant Support
Reg. No./Substance:
0/Dietary Fats; 0/Eicosanoids; 0/Fatty Acids, Omega-3

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