Document Detail


Dietary n-3 polyunsaturated fatty acid modulation of immune cell function before or after trauma.
MedLine Citation:
PMID:  7749236     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We describe the role of increased eicosanoid production in inducing immunodepression associated with shock and trauma and the potential mechanisms by which prostaglandins produce immunosuppression. The effects of prefeeding with a diet high in n-3 polyunsaturated fatty acids (PUFAs) in preventing trauma-induced immunosuppression, and of such a diet on cellular immunity in patients after trauma are described. The potential mechanisms by which enteral diets containing n-3 PUFAs produce beneficial effects are also discussed. Although there is controversy concerning the immunomodulatory mechanisms of this diet, most of the information available indicates that dietary supplementation with n-3 PUFAs may prevent immunosuppression after trauma. Further studies are needed, however, to determine the precise composition and duration of supplementation with n-3 PUFAs that prevent the deleterious immune responses but do not alter normal immunoresponsiveness.
Authors:
A Ayala; I H Chaudry
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  11     ISSN:  0899-9007     ISO Abbreviation:  Nutrition     Publication Date:    1995 Jan-Feb
Date Detail:
Created Date:  1995-06-22     Completed Date:  1995-06-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-11     Citation Subset:  IM    
Affiliation:
Department of Surgery, Michigan State University, East Lansing 48824, USA.
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MeSH Terms
Descriptor/Qualifier:
Dietary Fats / administration & dosage,  pharmacology*
Eicosanoids / biosynthesis,  physiology
Fatty Acids, Omega-3 / administration & dosage,  pharmacology*
Humans
Immunity*
Immunologic Deficiency Syndromes / etiology,  prevention & control
Wounds and Injuries / immunology*
Grant Support
ID/Acronym/Agency:
R01-GM-37127/GM/NIGMS NIH HHS; R29-GM-45354/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Eicosanoids; 0/Fatty Acids, Omega-3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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