| Dietary (n-3) fatty acids alter plasma fatty acids and leukotriene B synthesis by stimulated neutrophils from healthy geriatric Beagles. | |
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MedLine Citation:
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PMID: 16146686 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The study objective was to determine the effect of feeding food enriched in (n-3) fatty acids (FA) on plasma FA profiles and leukotriene B (LTB) synthesis by stimulated peripheral blood neutrophils from dogs. For 36 weeks, two groups of dogs (n = 5) were fed food that contained either a low ratio of (n-6)-(n-3) FA (1.31:1; fish oil-enriched food) or a high ratio of (n - 6)-(n-3) FA (40.6:1; corn oil-enriched food). Consumption of food enriched in fish oil resulted in higher plasma concentrations of eicosapentaenoic acid and docosahexaenoic acid and lower concentrations of arachidonic acid. Neutrophils from dogs fed fish oil-enriched food produced 7.6-fold more LTB(5)(P = 0.002), and the ratio of LTB(5)-LTB(4) concentrations was 8.3-fold higher (P < 0.001) compared with dogs fed corn oil-enriched food. Dietary FA can modulate leukotriene production by neutrophils in dogs, and suggests that foods enriched in (n-3) FA from fish oil may have value in the treatment of canine inflammatory diseases. |
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Authors:
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J A Hall; L R Henry; S Jha; M M Skinner; D E Jewell; R C Wander |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and essential fatty acids Volume: 73 ISSN: 0952-3278 ISO Abbreviation: Prostaglandins Leukot. Essent. Fatty Acids Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-09-27 Completed Date: 2006-03-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8802730 Medline TA: Prostaglandins Leukot Essent Fatty Acids Country: Scotland |
Other Details:
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Languages: eng Pagination: 335-41 Citation Subset: IM |
Affiliation:
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Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Dryden Hall 206, Corvallis, 97331, USA. jean.hall@oregonstate.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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metabolism* Animals Corn Oil / administration & dosage Diet Dogs Eating Eicosapentaenoic Acid / analogs & derivatives, biosynthesis, blood Fatty Acids / biosynthesis*, blood Fatty Acids, Omega-3 / administration & dosage* Female Leukotriene B4 / analogs & derivatives, biosynthesis*, blood Neutrophils / drug effects*, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Fatty Acids, Omega-3; 1553-41-9/Eicosapentaenoic Acid; 71160-24-2/Leukotriene B4; 8001-30-7/Corn Oil; 80445-66-5/leukotriene B5 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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