Document Detail

Dietary n-3 and n-6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the Doetinchem Cohort Study.
MedLine Citation:
PMID:  20484448     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The delta-5 and delta-6 desaturases, encoded by the FADS1 and FADS2 genes, are rate-limiting enzymes in polyunsaturated fatty acid (PUFA) biosynthesis. Single nucleotide polymorphisms in the FADS gene cluster region have been associated with both PUFA concentrations in plasma or erythrocyte membrane phospholipids and cholesterol concentrations in recent genome-wide association studies. OBJECTIVE: We examined whether genetic variations in the FADS gene cluster region interact with dietary intakes of n-3 (omega-3) and n-6 (omega-6) PUFAs to affect plasma total, HDL-, and non-HDL-cholesterol concentrations. DESIGN: Dietary intakes of n-3 and n-6 PUFAs, plasma concentrations of total and HDL cholesterol, and rs174546, rs482548, and rs174570 in the FADS gene cluster region were measured in 3575 subjects in the second survey of the Doetinchem Cohort Study. RESULTS: Significant associations between rs174546 genotypes and total and non-HDL-cholesterol concentrations were observed in the group with a high intake of n-3 PUFAs (> or =0.51% of total energy; P = 0.006 and 0.047, respectively) but not in the low-intake group (P for interaction = 0.32 and 0.51, respectively). The C allele was associated with high total and non-HDL-cholesterol concentrations. Furthermore, the C allele was significantly associated with high HDL-cholesterol concentrations in the group with a high intake of n-6 PUFAs (> or =5.26% of total energy, P = 0.004) but not in the group with a low intake (P for interaction = 0.02). CONCLUSION: Genetic variation in the FADS1 gene potentially interacts with dietary PUFA intakes to affect plasma cholesterol concentrations, which should be investigated further in other studies.
Yingchang Lu; Edith Jm Feskens; Martijn Et Dollé; Sandra Imholz; Wm Monique Verschuren; Michael Müller; Jolanda Ma Boer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-19
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  92     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-21     Completed Date:  2010-07-07     Revised Date:  2010-10-06    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  258-65     Citation Subset:  AIM; IM    
Division of Human Nutrition, Wageningen University Research Center, Wageningen, Netherlands.
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MeSH Terms
3' Untranslated Regions / genetics
Apolipoproteins B / blood
Cholesterol / blood*
Cholesterol, Dietary / metabolism
Cholesterol, HDL / blood*
Cohort Studies
Fatty Acid Desaturases / genetics*
Genetic Variation*
Genome, Human
Multigene Family / genetics
Polymorphism, Single Nucleotide
Reg. No./Substance:
0/3' Untranslated Regions; 0/Apolipoproteins B; 0/Cholesterol, Dietary; 0/Cholesterol, HDL; 57-88-5/Cholesterol; EC 1.14.19.-/Fatty Acid Desaturases; EC 1.14.99.-/delta-5 fatty acid desaturase

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