Document Detail

Dietary n-3 and n-6 polyunsaturated oils and airway contractility.
MedLine Citation:
PMID:  11418024     Owner:  NLM     Status:  MEDLINE    
Recent reports suggest modulation of chronic obstructive pulmonary disease by dietary polyunsaturated fatty acids. In the present study, we re-examined this possibility by using an established animal model of pulmonary sensitisation. Adult guinea pigs were fed diets supplemented (10% w/w) with either olive, canola or safflower oil for 4 weeks before sensitising with ovalbumin and continuing on various diets for a further 6 week period. Neither the contraction following ovalbumin challenge, nor the responses to histamine, carbachol and various eicosanoid mediators - prostaglandin F(2 alpha), leukotriene C(4), thromboxane mimetic U44619 - of isolated segments of airway tissue were altered (P>0.05, ANOVA) by the dietary lipid treatment. Lipid analysis showed changes in membrane linoleic acid (18:2n-6) and alpha -linolenic acids (alpha 18:3n-3) in lung phospholipids consistent with dietary intakes. However, no significant further desaturation/elongation of these dietary precursors was evident. Ovalbumin induced contraction was fully reversed by the lipoxygenase inhibitor esculetin whilst indomethacin resulted in a slight increase possibly due to the inhibition of bronchodilator prostanoids. Results confirm that under the conditions employed airway function was not influenced by the variable dietary intakes of n-3 and n-6 PUFA.
M Y Abeywardena; L T Jablonskis; R J Head
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  64     ISSN:  0952-3278     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:    2001 Apr-May
Date Detail:
Created Date:  2001-06-21     Completed Date:  2001-09-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  281-7     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Harcourt Publishers Ltd.
Health Sciences and Nutrition, CSIRO, Kintore Avenue, Adelaide, SA, 5000, Australia.
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MeSH Terms
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid / pharmacology
Analysis of Variance
Antioxidants / pharmacology
Bronchi / drug effects*
Carbachol / pharmacology
Cardiovascular Agents / pharmacology
Dietary Supplements
Dinoprost / pharmacology
Dose-Response Relationship, Drug
Fatty Acids / metabolism
Fatty Acids, Monounsaturated / pharmacology
Guinea Pigs
Histamine / pharmacology
Indomethacin / pharmacology
Leukotriene C4 / pharmacology
Linoleic Acid / pharmacology
Lipid Metabolism
Lung / metabolism
Ovalbumin / metabolism,  pharmacology
Plant Oils / pharmacology
Safflower Oil / pharmacology
Thromboxanes / pharmacology
Umbelliferones / pharmacology
Vasoconstrictor Agents / pharmacology
alpha-Linolenic Acid / pharmacology
Reg. No./Substance:
0/Antioxidants; 0/Cardiovascular Agents; 0/Fatty Acids; 0/Fatty Acids, Monounsaturated; 0/Plant Oils; 0/Thromboxanes; 0/Umbelliferones; 0/Vasoconstrictor Agents; 120962-03-0/canola oil; 2197-37-7/Linoleic Acid; 305-01-1/esculetin; 463-40-1/alpha-Linolenic Acid; 51-45-6/Histamine; 51-83-2/Carbachol; 53-86-1/Indomethacin; 551-11-1/Dinoprost; 72025-60-6/Leukotriene C4; 76898-47-0/15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8001-23-8/Safflower Oil; 8001-25-0/olive oil; 9006-59-1/Ovalbumin

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