| Dietary monounsaturated fat activates metabolic pathways for triglyceride-rich lipoproteins that involve apolipoproteins E and C-III. | |
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MedLine Citation:
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PMID: 18689361 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Dietary monounsaturated fat (MUFA) and complex carbohydrates have different effects on triglyceride-rich lipoprotein (TRL) metabolism. OBJECTIVE: We hypothesized that apolipoprotein (apo) E and apo C-III might be involved in these dietary effects because of their crucial role in TRL metabolism. DESIGN: Twelve adults consumed, for 3 wk each, 2 isocaloric diets: first a carbohydrate-rich diet (48% complex carbohydrate, 8% MUFAs) and then a MUFA-rich diet (31% complex carbohydrate, 24% MUFAs) 12 mo later. The dietary composition of other macronutrients in the 2 diets was similar. Body weight was kept constant. Postprandial apo B kinetic studies using stable-isotope tracers were performed after each dietary intervention. Multiple VLDL, intermediate-density lipoprotein (IDL), and LDL fractions were prepared on the basis of apo E and apo C-III contents. RESULTS: The MUFA diet increased by approximately 4-6-fold, the secretion of VLDLs and IDLs containing both apo E and apo C-III (E+CIII+) (P < 0.05). These are TRLs that mostly cleared from the circulation and are minor precursors of LDL. The MUFA diet also decreased by 60% (P < 0.05) the secretion of the TRLs without apo E or apo C-III (major precursors of LDL in plasma) and decreased their flux to LDLs. Total LDL flux did not change because the MUFA diet increased the flux to LDL from E-CIII+ TRLs, a process that requires the removal of apo C-III. In addition, the MUFA diet significantly increased the TRL fractional catabolic rate by 50% and doubled the percentage of TRLs that were cleared rather than being converted to LDLs. CONCLUSION: MUFA intake activates synthetic and rapid catabolic pathways for TRL metabolism that involve apo E and apo C-III and suppresses the metabolism of more slowly metabolized VLDLs and IDLs, which do not contain these apolipoproteins. |
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Authors:
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Chunyu Zheng; Christina Khoo; Jeremy Furtado; Katsunori Ikewaki; Frank M Sacks |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 88 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-11 Completed Date: 2008-09-12 Revised Date: 2011-10-24 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 272-81 Citation Subset: AIM; IM |
Affiliation:
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Department of Nutrition, Harvard School of Public Health, Boston, MA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apolipoprotein C-III
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blood,
metabolism* Apolipoproteins E / blood, metabolism* Cholesterol, LDL / blood, metabolism Cholesterol, VLDL / blood, metabolism Cross-Over Studies Diet* Dietary Carbohydrates / administration & dosage, metabolism Dose-Response Relationship, Drug Fatty Acids, Monounsaturated / administration & dosage*, metabolism Female Humans Kinetics Lipids / blood Lipoproteins / blood*, metabolism Male Middle Aged Triglycerides / blood, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR002635-140572/RR/NCRR NIH HHS; M01 RR002635-150572/RR/NCRR NIH HHS; M01 RR002635-160572/RR/NCRR NIH HHS; M01 RR002635-170572/RR/NCRR NIH HHS; M01 RR002635-180572/RR/NCRR NIH HHS; M01 RR002635-190572/RR/NCRR NIH HHS; M01 RR002635-200675/RR/NCRR NIH HHS; M01 RR002635-210675/RR/NCRR NIH HHS; M01 RR002635-225334/RR/NCRR NIH HHS; P30 DK040561-13/DK/NIDDK NIH HHS; R01 HL056210-03/HL/NHLBI NIH HHS; R01 HL056210-04/HL/NHLBI NIH HHS; R01 HL056210-05/HL/NHLBI NIH HHS; R01-HL-34980/HL/NHLBI NIH HHS; R01-HL-56210/HL/NHLBI NIH HHS; RR02635/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein C-III; 0/Apolipoproteins E; 0/Cholesterol, LDL; 0/Cholesterol, VLDL; 0/Dietary Carbohydrates; 0/Fatty Acids, Monounsaturated; 0/Lipids; 0/Lipoproteins; 0/Triglycerides |
| Comments/Corrections | |
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