| Dietary mold oil rich in gamma linolenic acid increases insulin-dependent glucose utilization in isolated rat adipocytes. | |
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MedLine Citation:
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PMID: 11567903 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Effects of dietary fats differing in fatty acid composition on insulin-stimulated glucose metabolism in adipocytes isolated from rat white adipose tissue were compared. Rats were fed experimental diets containing various fats differing in fatty acid composition for 7 days. In the first experiment, rats were fed palm oil mainly consisting of palmitic (45.3%) and oleic acids (39.1%) or safflower oil rich in linoleic acid (71.6%). In the second trial, rats were fed palm oil, or a fat mixture rich in linoleic acid or mold oil rich in gamma-linolenic acid. Contents of fatty acids except for linoleic and gamma-linolenic acid were comparable between the fat mixture and mold oil. The former was devoid of gamma-linolenic acid and contained 42.0% linoleic acid, while the latter contained 25.9% gamma-linolenic and 15.7% linoleic acids. In the first experiment, the insulin-dependent increase in glucose oxidation and incorporation into lipids was higher in rats fed safflower oil compared to those fed palm oil. In the second experiment, the insulin-dependent increase in glucose oxidation and incorporation into lipids was higher in rats fed the fat mixture and mold oil than in those fed palm oil. However, the extent of the increase in these parameters was much greater in rats fed mold oil than in those fed the fat mixture. Therefore, dietary gamma-linolenic acid compared to linoleic acid increases glucose metabolism in response to insulin stimuli in isolated rat adipocytes. |
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Authors:
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T Ide; M Kushiro; Y Takahashi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology Volume: 130 ISSN: 1096-4959 ISO Abbreviation: Comp. Biochem. Physiol. B, Biochem. Mol. Biol. Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-09-24 Completed Date: 2002-01-31 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9516061 Medline TA: Comp Biochem Physiol B Biochem Mol Biol Country: England |
Other Details:
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Languages: eng Pagination: 401-9 Citation Subset: IM |
Affiliation:
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Laboratory of Nutrition Biochemistry, National Food Research Institute, 2-1-12 Kannondai, Tsukuba Science City, 305-8642, Ibaraki, Japan. idetaka@nfri.affrc.go.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipocytes
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drug effects*,
metabolism* Adipose Tissue / cytology, drug effects, metabolism Animals Blood Glucose / metabolism Body Weight / drug effects Diet Dietary Fats / administration & dosage, pharmacology* Glucose / metabolism* Insulin / pharmacology Lipid Metabolism Lipids / blood Male Oleic Acids / administration & dosage, pharmacology Organ Size / drug effects Palmitic Acids / administration & dosage, pharmacology Plant Oils / administration & dosage, pharmacology Rats Rats, Sprague-Dawley gamma-Linolenic Acid / administration & dosage, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Dietary Fats; 0/Lipids; 0/Oleic Acids; 0/Palmitic Acids; 0/Plant Oils; 11061-68-0/Insulin; 50-99-7/Glucose; 506-26-3/gamma-Linolenic Acid; 8002-75-3/palm oil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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