Document Detail

Dietary modulation of oxidative stress in chronic obstructive pulmonary disease patients.
MedLine Citation:
PMID:  20815775     Owner:  NLM     Status:  MEDLINE    
A total of 267 clinically stable chronic obstructive pulmonary disease (COPD) patients provided complete data about diet and oxidative stress markers in order to assess the relationship between antioxidant rich food groups and nutrients, and serum markers of oxidative stress in COPD. Dietary data of the last 2 years was assessed using a validated food frequency questionnaire (122 items). Levels of carbonyls, nitrotyrosine, malondialdehyde and reduced glutathione (GSH) were measured in serum. Vitamin E intake was inversely associated with levels of carbonyls (p = 0.05) and olive oil was positively associated with GSH levels (p = 0.01), in active smokers. Intake of vegetables was related to a decrease of malondialdehyde levels (p = 0.04) in former smokers. No statistically significant associations were found between remaining dietary antioxidants and serum oxidative stress markers. These results provide new data for a potential dietary modulation of systemic oxidative stress in COPD patients, particularly in those that continue smoking.
Jordi de Batlle; Esther Barreiro; Isabelle Romieu; Michelle Mendez; Federico P Gómez; Eva Balcells; Jaume Ferrer; Mauricio Orozco-Levi; Joaquim Gea; Josep M Antó; Judith Garcia-Aymerich
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Free radical research     Volume:  44     ISSN:  1029-2470     ISO Abbreviation:  Free Radic. Res.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-14     Completed Date:  2011-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423872     Medline TA:  Free Radic Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1296-303     Citation Subset:  IM    
Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
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MeSH Terms
Antioxidants / metabolism
Cross-Sectional Studies
Oxidative Stress / physiology*
Pulmonary Disease, Chronic Obstructive / metabolism*,  physiopathology
Smoking / adverse effects
Reg. No./Substance:

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