Document Detail


Dietary modulation of the multistage, multimechanisms of human carcinogenesis: effects on initiated stem cells and cell-cell communication.
MedLine Citation:
PMID:  16800778     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Diet can influence the risk to cancer in both negative and positive ways. Worldwide, more than 10 million persons develop cancer annually. Diet could prevent many cancers. Carcinogenesis is a multistage, multimechanism process, consisting of "initiation," "promotion," and "progression" phases. Although diet could affect each phase, an efficacious strategy for dietary chemoprevention would be intervention during the promotion phase. The tumor-promotion process requires sustained exposure to agents that stimulate the growth and inhibition of apoptosis of initiated cells in the absence of antipromoters. Chronic inflammation has been associated with the promotion process. The mechanism affecting the promotion process appears to be the inhibition of cell-cell communication between normal and initiated cells. Most, if not all, tumor-promoting agents and conditions, reversibly, inhibit cell-cell communication, whereas antipromoters, antioxidants, and anti-inflammatory agents have been shown to ameliorate the effects of tumor promoters on cell-cell communication. Additionally, adult stem cells are hypothesized to be the target cells for initiating the carcinogenic process. A new paradigm has been presented that postulates the first function of the carcinogenic process is to block the "mortalization" of a normal, "immortal" adult stem cell rather than the induction of "immortalization" of a normal mortal cell.
Authors:
James E Trosko
Related Documents :
8668128 - Dominant mutant alleles of yeast protein kinase gene cdc15 suppress the lte1 defect in ...
17519288 - Nuclear localization of barrier-to-autointegration factor is correlated with progressio...
7901938 - The number of proliferating cell nuclear antigen positive cells in endometriotic lesion...
1628758 - Dna synthesis in the early embryo of the nematode ascaris suum.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Nutrition and cancer     Volume:  54     ISSN:  0163-5581     ISO Abbreviation:  Nutr Cancer     Publication Date:  2006  
Date Detail:
Created Date:  2006-06-27     Completed Date:  2006-11-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7905040     Medline TA:  Nutr Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  102-10     Citation Subset:  IM    
Affiliation:
246 National Food Safety Toxicology Center, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing 48824, USA. james.trosko@th.msu.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Anticarcinogenic Agents
Antineoplastic Agents
Antioxidants
Apoptosis
Cell Communication*
Diet*
Gap Junctions / physiology
Homeostasis
Humans
Inflammation
Neoplasms / pathology,  physiopathology,  prevention & control*
Stem Cells / pathology*
Grant Support
ID/Acronym/Agency:
P42 ES04911/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Anticarcinogenic Agents; 0/Antineoplastic Agents; 0/Antioxidants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Bilberry extracts induce gene expression through the electrophile response element.
Next Document:  Fruit and vegetables in cancer prevention.