| Dietary modulation of the multistage, multimechanisms of human carcinogenesis: effects on initiated stem cells and cell-cell communication. | |
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MedLine Citation:
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PMID: 16800778 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Diet can influence the risk to cancer in both negative and positive ways. Worldwide, more than 10 million persons develop cancer annually. Diet could prevent many cancers. Carcinogenesis is a multistage, multimechanism process, consisting of "initiation," "promotion," and "progression" phases. Although diet could affect each phase, an efficacious strategy for dietary chemoprevention would be intervention during the promotion phase. The tumor-promotion process requires sustained exposure to agents that stimulate the growth and inhibition of apoptosis of initiated cells in the absence of antipromoters. Chronic inflammation has been associated with the promotion process. The mechanism affecting the promotion process appears to be the inhibition of cell-cell communication between normal and initiated cells. Most, if not all, tumor-promoting agents and conditions, reversibly, inhibit cell-cell communication, whereas antipromoters, antioxidants, and anti-inflammatory agents have been shown to ameliorate the effects of tumor promoters on cell-cell communication. Additionally, adult stem cells are hypothesized to be the target cells for initiating the carcinogenic process. A new paradigm has been presented that postulates the first function of the carcinogenic process is to block the "mortalization" of a normal, "immortal" adult stem cell rather than the induction of "immortalization" of a normal mortal cell. |
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Authors:
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James E Trosko |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Nutrition and cancer Volume: 54 ISSN: 0163-5581 ISO Abbreviation: Nutr Cancer Publication Date: 2006 |
Date Detail:
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Created Date: 2006-06-27 Completed Date: 2006-11-14 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7905040 Medline TA: Nutr Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 102-10 Citation Subset: IM |
Affiliation:
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246 National Food Safety Toxicology Center, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing 48824, USA. james.trosko@th.msu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anticarcinogenic Agents Antineoplastic Agents Antioxidants Apoptosis Cell Communication* Diet* Gap Junctions / physiology Homeostasis Humans Inflammation Neoplasms / pathology, physiopathology, prevention & control* Stem Cells / pathology* |
| Grant Support | |
ID/Acronym/Agency:
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P42 ES04911/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anticarcinogenic Agents; 0/Antineoplastic Agents; 0/Antioxidants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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