| Dietary lipids from an evolutionary perspective: sources, structures and functions. | |
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MedLine Citation:
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PMID: 21366863 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Lipids are a complex group of biomolecules whose precise functions remain poorly understood. As a result of this poor understanding, it is difficult to make mechanistically based recommendations for appropriate dietary intakes. It is equally difficult to develop methods that are capable of diagnosing functional impairments because of insufficiencies or excesses in particular fatty acids. Lipids are abundant building blocks of cellular membranes, supply components for lipid particle assembly and substrates for metabolic fuel, and provide a precursor pool for an astonishingly diverse range of signalling molecules. In each of these broad functions, the functional consequences of different structures of fatty acids are not fully understood. According to research on membrane functions through early evolution, docosahexaenoic acid provides two biophysical properties to membranes - accelerating the lateral motion of lipids and proteins within the plane of the membrane and simultaneously slowing the rate of diffusion/leakage of charged species across the plane of the membrane. The range of fatty acid structures used as substrates for assembly of either lipoproteins or milk fat globules is broad, yet the functional consequences of differences are not known. Different lipids signal into a remarkable range of biological processes. Saturated and monounsaturated fatty acids are becoming recognized as signal molecules in their own right. The complex composition of human milk lipids implies that diets with a diversity of fatty acids in complex lipid forms and structures is more beneficial than a narrow range of any particular group of fatty acids. |
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Authors:
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J Bruce German |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Maternal & child nutrition Volume: 7 Suppl 2 ISSN: 1740-8709 ISO Abbreviation: Matern Child Nutr Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101201025 Medline TA: Matern Child Nutr Country: England |
Other Details:
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Languages: eng Pagination: 2-16 Citation Subset: IM |
Copyright Information:
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© 2011 Blackwell Publishing Ltd. |
Affiliation:
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Department of Food Science and Technology, University of California, Davis, California 95616, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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