| Dietary lipids alter the effect of steroids on the transport of fructose following intestinal resection in rats. | |
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MedLine Citation:
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PMID: 18270839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Glucocorticosteroids alter intestinal morphology and transport. We tested the hypothesis that the desired intestinal adaptive response following intestinal resection may be enhanced further by the locally active steroid budesonide, and by feeding a saturated as compared with a polyunsaturated fatty acid diet. METHODS: An in-vitro uptake method was used to assess intestinal fructose uptake by rats of semisynthetic diets enriched in saturated or polyunsaturated fatty acids, and injected with budesonide or control solution. RESULTS: Budesonide increased ileal fructose uptake in chow and PUFA-fed animals, but reduced jejunal fructose uptake in rats fed SFA. GLUT5 and GLUT2 protein and mRNA did not correlate with changes in fructose uptake. Steroids reduced jejunal proglucagon expression in animals fed chow. Animals fed SFA and given budesonide had a reduction in jejunal ODC mRNA compared with those fed PUFA or chow. CONCLUSIONS: (1) budesonide increases ileal fructose uptake following intestinal resection, and this beneficial effect is prevented by feeding SFA rather than PUFA; (2) fructose uptake does not correlate with GLUT5 and GLUT2 protein and mRNA; (3) ODC and proglucagon may be involved in this adaptive response. |
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Authors:
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A Thiesen; K A Tappenden; M I McBurney; M T Clandinin; M Keelan; B K A Thomson; L A Drozdowski; G Wild; A B R Thomson |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-02-13 |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 53 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-02 Completed Date: 2008-08-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 2126-39 Citation Subset: AIM; IM |
Affiliation:
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Nutrition and Metabolism Research Group, Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological Animals Budesonide / pharmacology* Fatty Acids / pharmacology* Fatty Acids, Unsaturated / pharmacology* Fructose / metabolism* Glucocorticoids / pharmacology* Glucose Transporter Type 2 / genetics, metabolism Glucose Transporter Type 5 / genetics, metabolism Ileum / drug effects, metabolism Intestinal Absorption / drug effects* Intestine, Small / drug effects*, metabolism, surgery Jejunum / drug effects, metabolism Male Postoperative Period Proglucagon / metabolism RNA, Messenger / metabolism Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Fatty Acids, Unsaturated; 0/Glucocorticoids; 0/Glucose Transporter Type 2; 0/Glucose Transporter Type 5; 0/RNA, Messenger; 0/Slc2a2 protein, rat; 0/Slc2a5 protein, rat; 30237-26-4/Fructose; 51333-22-3/Budesonide; 55963-74-1/Proglucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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